Prospective Multicenter Study of the Safety of Gadoteridol in 6163 Patients
DC Field | Value | Language |
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dc.contributor.author | Cho, Sung Bum | - |
dc.contributor.author | Lee, A-Leum | - |
dc.contributor.author | Chang, Hyuk Won | - |
dc.contributor.author | Kim, Kyeong Ah | - |
dc.contributor.author | Yoo, Won Jong | - |
dc.contributor.author | Yeom, Jeong A. | - |
dc.contributor.author | Rho, Myung Ho | - |
dc.contributor.author | Kim, Sung Jin | - |
dc.contributor.author | Lim, Yun-jung | - |
dc.contributor.author | Han, Miran | - |
dc.date.accessioned | 2021-08-31T08:57:21Z | - |
dc.date.available | 2021-08-31T08:57:21Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 1053-1807 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/57539 | - |
dc.description.abstract | Background The safety of gadolinium-based contrast agents is of fundamental importance. Purpose To determine the frequency and severity of immediate-type adverse reactions to approved doses of gadoteridol in patients referred for routine gadoteridol-enhanced MRI in actual clinical practice settings. Study Type Prospective, observational. Population In all, 6163 subjects were enrolled (mean age: 56.7 +/- 15.4 years; range: 6-93 years). Field Strength/Sequence 1.5T and 3.0T. Assessment Assessment was of immediate adverse reactions by the investigating radiologist using the MedDRA System Organ Class and preferred term. Statistical Tests Summary statistics for continuous variables, descriptive statistics for demographic characteristics. Results Overall, 19 adverse events occurred in 13 (0.21%) patients, of which 15 in 10 (0.16%) patients were considered related to gadoteridol administration. These events were evenly distributed between male and female subjects and all occurred in adults. Twelve of the 15 related events in eight (0.13%) patients were considered mild in intensity (rapidly self-resolving), while the remaining three events in two patients (0.03%) were considered moderate in intensity. None were of severe intensity and no serious adverse events occurred. Data Conclusion The rate of immediate-type adverse events following exposure to approved doses of gadoteridol is extremely low, and mostly limited to transient and self-resolving symptoms. Technical Efficacy Stage: 5 J. Magn. Reson. Imaging 2019. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | GADOLINIUM CONTRAST AGENTS | - |
dc.subject | GADOBENATE DIMEGLUMINE | - |
dc.subject | BRAIN | - |
dc.subject | ADMINISTRATIONS | - |
dc.subject | GADOBUTROL | - |
dc.subject | DEPOSITION | - |
dc.subject | MEGLUMINE | - |
dc.subject | RATES | - |
dc.subject | RISK | - |
dc.subject | MRI | - |
dc.title | Prospective Multicenter Study of the Safety of Gadoteridol in 6163 Patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cho, Sung Bum | - |
dc.contributor.affiliatedAuthor | Kim, Kyeong Ah | - |
dc.identifier.doi | 10.1002/jmri.26940 | - |
dc.identifier.scopusid | 2-s2.0-85074326619 | - |
dc.identifier.wosid | 000493085400001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MAGNETIC RESONANCE IMAGING, v.51, no.3, pp.861 - 868 | - |
dc.relation.isPartOf | JOURNAL OF MAGNETIC RESONANCE IMAGING | - |
dc.citation.title | JOURNAL OF MAGNETIC RESONANCE IMAGING | - |
dc.citation.volume | 51 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 861 | - |
dc.citation.endPage | 868 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | GADOLINIUM CONTRAST AGENTS | - |
dc.subject.keywordPlus | GADOBENATE DIMEGLUMINE | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | ADMINISTRATIONS | - |
dc.subject.keywordPlus | GADOBUTROL | - |
dc.subject.keywordPlus | DEPOSITION | - |
dc.subject.keywordPlus | MEGLUMINE | - |
dc.subject.keywordPlus | RATES | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordAuthor | gadolinium-based contrast agents | - |
dc.subject.keywordAuthor | contrast agent safety | - |
dc.subject.keywordAuthor | adverse reactions | - |
dc.subject.keywordAuthor | gadoteridol | - |
dc.subject.keywordAuthor | prospective | - |
dc.subject.keywordAuthor | observational studies | - |
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