Comparison between in vitro toxicities of tobacco- and menthol-flavored electronic cigarette liquids on human middle ear epithelial cells
DC Field | Value | Language |
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dc.contributor.author | Go, Yoon Young | - |
dc.contributor.author | Mun, Ji Yoen | - |
dc.contributor.author | Chae, Sung-Won | - |
dc.contributor.author | Chang, Jiwon | - |
dc.contributor.author | Song, Jae-Jun | - |
dc.date.accessioned | 2021-08-31T10:15:36Z | - |
dc.date.available | 2021-08-31T10:15:36Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-02-13 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/57664 | - |
dc.description.abstract | Since electronic-cigarettes (e-cigarettes) are considered less toxic than conventional tobacco smoking, the use of e-cigarettes has increased, and the market for e-cigarette liquids (e-liquids) is continuously increasing. However, many studies showed that e-cigarettes may cause various harmful effects in lung, oral and heart. In this study, we investigated the effects of e-liquids on otitis media (OM) using human middle ear epithelial cells (HMEECs). Menthol-flavored e-liquid induced significant cell death in HMEECs (IC50: 1.45 +/- 0.14%) and tobacco-flavored e-liquid led to increase in inflammatory cytokine levels and higher mucin production. Flavored e-liquids decreased the mRNA levels of genes encoding epithelial sodium channels (ENaCs) in HMEECs. Apoptosis and autophagy reactions were induced by exposure of HMEECs to menthol- and tobacco-flavored e-liquids. Tobacco-flavored e-liquids caused a greater increase in the levels of autophagosome marker, LC3-II, compared to menthol-flavored e-liquids, which was followed by cell death. These results demonstrate that flavored e-liquids cause cytotoxicity via apoptosis, autophagy, inflammatory response, and mucin production in HMEECs. The flavors present in e-liquids might be a risk factor for the development of otitis media. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | MUCIN GENE-EXPRESSION | - |
dc.subject | ASIAN SAND DUST | - |
dc.subject | OTITIS-MEDIA | - |
dc.subject | PARTICLES | - |
dc.subject | ALPHA | - |
dc.title | Comparison between in vitro toxicities of tobacco- and menthol-flavored electronic cigarette liquids on human middle ear epithelial cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Go, Yoon Young | - |
dc.contributor.affiliatedAuthor | Song, Jae-Jun | - |
dc.identifier.doi | 10.1038/s41598-020-59290-y | - |
dc.identifier.scopusid | 2-s2.0-85079339209 | - |
dc.identifier.wosid | 000562888500020 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.10, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | MUCIN GENE-EXPRESSION | - |
dc.subject.keywordPlus | ASIAN SAND DUST | - |
dc.subject.keywordPlus | OTITIS-MEDIA | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | ALPHA | - |
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