M2 macrophages predict worse long-term outcomes in human acute tubular necrosis
DC Field | Value | Language |
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dc.contributor.author | Kim, Myung-Gyu | - |
dc.contributor.author | Lim, Kijoon | - |
dc.contributor.author | Lee, Yoo Jin | - |
dc.contributor.author | Yang, Jihyun | - |
dc.contributor.author | Oh, Se Won | - |
dc.contributor.author | Cho, Won Yong | - |
dc.contributor.author | Jo, Sang-Kyung | - |
dc.date.accessioned | 2021-08-31T10:36:49Z | - |
dc.date.available | 2021-08-31T10:36:49Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-02-07 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/57683 | - |
dc.description.abstract | Although macrophages are important players in the injury/repair processes in animal models of acute kidney injury (AKI), their roles in human AKI remains uncertain owing to a paucity of human biopsy studies. We investigated the role of macrophages in 72 cases of biopsy-proven acute tubular necrosis (ATN) and six cases of healthy kidney. Macrophages were identified by CD68 and CD163 immunohistochemistry and analyzed for their effect on renal outcomes. CD163+ M2 macrophages outnumbered CD68+ cells in the healthy kidneys, suggesting that CD163+ macrophages are resident macrophages. The infiltration of both subtypes of macrophages increased significantly in ATN. The density of the CD68+ macrophages was significantly higher in advanced-stage AKI, whereas CD163+ M2 macrophages was not. Eighty percent of patients exhibited renal functional recovery during follow-up. Older age and a higher density of CD163+ macrophages predicted non-recovery, whereas the AKI stage, tubular injury score, and density of CD68+ cells did not. The density of CD163+ M2 macrophages was an independent predictor of low eGFR at 3 months in advanced-stage AKI. This is the first human study demonstrating the possible role of macrophages in the injury and repair phases of AKI. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | ACUTE KIDNEY INJURY | - |
dc.subject | AKI | - |
dc.subject | CONTRIBUTE | - |
dc.subject | EXPRESSION | - |
dc.subject | PHENOTYPE | - |
dc.subject | CD163 | - |
dc.subject | CELLS | - |
dc.title | M2 macrophages predict worse long-term outcomes in human acute tubular necrosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Myung-Gyu | - |
dc.contributor.affiliatedAuthor | Lee, Yoo Jin | - |
dc.contributor.affiliatedAuthor | Oh, Se Won | - |
dc.contributor.affiliatedAuthor | Cho, Won Yong | - |
dc.contributor.affiliatedAuthor | Jo, Sang-Kyung | - |
dc.identifier.doi | 10.1038/s41598-020-58725-w | - |
dc.identifier.scopusid | 2-s2.0-85079080867 | - |
dc.identifier.wosid | 000562829600007 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.10, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ACUTE KIDNEY INJURY | - |
dc.subject.keywordPlus | AKI | - |
dc.subject.keywordPlus | CONTRIBUTE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PHENOTYPE | - |
dc.subject.keywordPlus | CD163 | - |
dc.subject.keywordPlus | CELLS | - |
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