CCR4-NOT transcription complex subunit 2 regulates TRAIL sensitivity in non-small-cell lung cancer cells via the STAT3 pathway
DC Field | Value | Language |
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dc.contributor.author | Kim, Eun-Ok | - |
dc.contributor.author | Kang, Shi-Eun | - |
dc.contributor.author | Choi, Minji | - |
dc.contributor.author | Rhee, Ki-Jong | - |
dc.contributor.author | Yun, Miyong | - |
dc.date.accessioned | 2021-08-31T11:29:22Z | - |
dc.date.available | 2021-08-31T11:29:22Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/57831 | - |
dc.description.abstract | TRAIL is an attractive candidate for anticancer therapy in a variety of tumors since it targets only tumors and not normal tissue. However, a remaining major hurdle is that the majority of tumors exhibit a resistance mechanism against the effects of TRAIL via the induction of anti-apoptotic signaling pathways. In this study, we aimed to evaluate whether the modulation of CCR4-NOT transcription complex subunit 2 (CNOT2) function can promote TRAIL sensitivity in non-small-cell lung cancer (NSCLC) cells. CNOT2 depletion partially decreased colony numbers and the proliferation of NSCLC cells. When combined with TRAIL, the suppression of CNOT2 expression markedly decreased the survival rate and increased apoptosis, as compared with TRAIL treatment alone in TRAIL-resistant NSCLC cells. Of note, CNOT2 overexpression in TRAIL-sensitive H460 cells enhanced the survival rate and decreased apoptosis when compared with TRAIL treatment alone. Gene expression analysis indicated that genes involved in the signal transducer and activator of transcription 3 (STAT3) signaling pathway were dominantly altered in the CNOT2-depleted A549 cells. Under this condition, Src homology region 2 domain containing phosphatase-1 (SHP1) was significantly upregulated and subsequently increased apoptosis. On the whole, the findings of this study demonstrate that CNOT2 participates in TRAIL sensitivity in NSCLC cells via the regulation of the STAT3 signaling pathway, and suggest that combination therapy with CNOT2 depletion and TRAIL treatment may prove to be a useful strategy for overcoming TRAIL resistance in NSCLC. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | DEATH RECEPTORS 4 | - |
dc.subject | SIGNAL TRANSDUCER | - |
dc.subject | TUMOR-SUPPRESSOR | - |
dc.subject | APOPTOSIS | - |
dc.subject | ACTIVATOR | - |
dc.subject | CNOT2 | - |
dc.subject | PROLIFERATION | - |
dc.subject | CONTRIBUTES | - |
dc.subject | EXPRESSION | - |
dc.subject | REPRESSION | - |
dc.title | CCR4-NOT transcription complex subunit 2 regulates TRAIL sensitivity in non-small-cell lung cancer cells via the STAT3 pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Eun-Ok | - |
dc.identifier.doi | 10.3892/ijmm.2019.4425 | - |
dc.identifier.scopusid | 2-s2.0-85077782215 | - |
dc.identifier.wosid | 000513554900004 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, v.45, no.2, pp.324 - 332 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.citation.volume | 45 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 324 | - |
dc.citation.endPage | 332 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | DEATH RECEPTORS 4 | - |
dc.subject.keywordPlus | SIGNAL TRANSDUCER | - |
dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | ACTIVATOR | - |
dc.subject.keywordPlus | CNOT2 | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | CONTRIBUTES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | REPRESSION | - |
dc.subject.keywordAuthor | CNOT2 | - |
dc.subject.keywordAuthor | TRAIL | - |
dc.subject.keywordAuthor | non-small cell lung cancer | - |
dc.subject.keywordAuthor | STAT3 | - |
dc.subject.keywordAuthor | endoplasmic reticulum stress | - |
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