In vitro evaluation of Pt-coated electrospun nanofibers for endovascular coil embolization
DC Field | Value | Language |
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dc.contributor.author | Kim, Min-Woo | - |
dc.contributor.author | An, Seongpil | - |
dc.contributor.author | Seok, Hyunjun | - |
dc.contributor.author | Jung, Hyunchul | - |
dc.contributor.author | Park, Dong-Hyuk | - |
dc.contributor.author | Yarin, Alexander L. | - |
dc.contributor.author | Yoon, Sam S. | - |
dc.date.accessioned | 2021-08-31T14:45:07Z | - |
dc.date.available | 2021-08-31T14:45:07Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-01-01 | - |
dc.identifier.issn | 1742-7061 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/58371 | - |
dc.description.abstract | Recently, endovascular coil embolization has been introduced to treat intracranial aneurysms because it has lower morbidity and mortality than surgical clipping. The endovascular coils prevent the extravasation of blood by decreasing the permeability of an aneurysm flow governed by Darcy's law. Here, we developed and explored Pt-coated micro-ropes for potential use as endovascular coils. Electrospinning with subsequent electroplating were employed to fabricate Pt-coated nanofibers, which were tightly twisted to form micro-ropes. The compatibility of Pt micro-ropes with commercial delivery catheters was verified and their performance was experimentally explored in an in vitro experimental model. The developed Pt-coated micro-ropes demonstrated feasibility as efficient and low-cost endovascular coils. Statement of Significance The use of Platinum (Pt)-coated polymer nanofibers to prevent blood extravasation has been demonstrated. These Pt nanofibers were installed within a microfluidic channel, and the resulting reduced permeability was evaluated using a fluid similar to blood. Based on the obtained results, these newly developed nanofibers are expected to decrease the operation cost for aneurysmal subarachnoid hemorrhage (SAH), owing their reduced size and low material cost. Overall, the use of this new material should reduce the operational risk associated with the multiple steps required to place the Pt coils at the SAH site. The compatibility of Pt micro -ropes with commercial delivery catheters was verified and their performance was experimentally explored in an in vitro experimental model. The developed Pt-coated micro -ropes demonstrated feasibility as efficient and low-cost endovascular coils. (C) 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | BARE PLATINUM COILS | - |
dc.subject | INTRACRANIAL ANEURYSMS | - |
dc.subject | NANOPARTICLES | - |
dc.subject | PALLADIUM | - |
dc.subject | SYSTEM | - |
dc.subject | SAFETY | - |
dc.subject | SENSOR | - |
dc.title | In vitro evaluation of Pt-coated electrospun nanofibers for endovascular coil embolization | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Dong-Hyuk | - |
dc.contributor.affiliatedAuthor | Yoon, Sam S. | - |
dc.identifier.doi | 10.1016/j.actbio.2019.10.015 | - |
dc.identifier.scopusid | 2-s2.0-85074500188 | - |
dc.identifier.wosid | 000504504300021 | - |
dc.identifier.bibliographicCitation | ACTA BIOMATERIALIA, v.101, pp.285 - 292 | - |
dc.relation.isPartOf | ACTA BIOMATERIALIA | - |
dc.citation.title | ACTA BIOMATERIALIA | - |
dc.citation.volume | 101 | - |
dc.citation.startPage | 285 | - |
dc.citation.endPage | 292 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | BARE PLATINUM COILS | - |
dc.subject.keywordPlus | INTRACRANIAL ANEURYSMS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | PALLADIUM | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | SAFETY | - |
dc.subject.keywordPlus | SENSOR | - |
dc.subject.keywordAuthor | Endovascular coil embolization | - |
dc.subject.keywordAuthor | Aneurysm | - |
dc.subject.keywordAuthor | Electrospinning | - |
dc.subject.keywordAuthor | Platinum nanofiber | - |
dc.subject.keywordAuthor | Permeability | - |
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