Correlation of serum interleukin-31 with pruritus and blood eosinophil markers in children with atopic dermatitis
DC Field | Value | Language |
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dc.contributor.author | Byeon, Jung Hye | - |
dc.contributor.author | Yoon, Wonsuck | - |
dc.contributor.author | Ahn, So Hyun | - |
dc.contributor.author | Lee, Hyo Sun | - |
dc.contributor.author | Kim, Seunghyun | - |
dc.contributor.author | Yoo, Young | - |
dc.date.accessioned | 2021-08-31T14:46:34Z | - |
dc.date.available | 2021-08-31T14:46:34Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-01-01 | - |
dc.identifier.issn | 1088-5412 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/58380 | - |
dc.description.abstract | Background: Atopic dermatitis (AD) is chronic pruritic inflammatory skin disease in children. Interleukin (IL) 31 is a recently discovered cytokine associated with chronic skin inflammation and pruritus. Objectives: The aims of this study were to determine whether serum IL-31 levels are increased in children with AD and to examine the relationship between IL-31 and other clinical biomarkers in AD. Methods: Serum cytokine levels, including IL-31, IL-4, and IL-12, were measured in 38 patients with AD and 10 healthy children. Peripheral blood eosinophils, serum immunoglobulin E levels, eosinophil cationic protein, and thymic stromal lymphopoietin (TSLP) were measured. We also estimated the clinical severity of AD by using the Scoring Atopic Dermatitis (SCORAD) index by a single clinician. Results: The serum IL-31 levels were significantly higher in the patients with AD than in the healthy children. IL-31 correlated well with the SCORAD index and blood eosinophilic inflammatory markers. The serum level of TSLP was also higher in patients with AD than in the healthy children; however, levels of IL-4 and IL-12 were not different between AD and healthy children. There was no significant difference in serum IL-31 levels between patients with atopic AD and nonatopic AD. Conclusion: This study showed that serum IL-31 levels were significantly elevated in patients with AD than in the healthy children and correlated well with disease severity. IL-31 seemed to be one of the cytokines that induce pruritus and eosinophilic inflammation in AD. Serum IL-31 correlated with pruritic symptoms and disease course of AD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OCEAN SIDE PUBLICATIONS INC | - |
dc.subject | CATIONIC PROTEIN | - |
dc.subject | DISEASE-ACTIVITY | - |
dc.subject | T-CELLS | - |
dc.subject | IL-31 | - |
dc.subject | EXPRESSION | - |
dc.title | Correlation of serum interleukin-31 with pruritus and blood eosinophil markers in children with atopic dermatitis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Byeon, Jung Hye | - |
dc.contributor.affiliatedAuthor | Yoon, Wonsuck | - |
dc.contributor.affiliatedAuthor | Yoo, Young | - |
dc.identifier.doi | 10.2500/aap.2020.41.190016 | - |
dc.identifier.scopusid | 2-s2.0-85077337386 | - |
dc.identifier.wosid | 000505060600015 | - |
dc.identifier.bibliographicCitation | ALLERGY AND ASTHMA PROCEEDINGS, v.41, no.1, pp.59 - 65 | - |
dc.relation.isPartOf | ALLERGY AND ASTHMA PROCEEDINGS | - |
dc.citation.title | ALLERGY AND ASTHMA PROCEEDINGS | - |
dc.citation.volume | 41 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 59 | - |
dc.citation.endPage | 65 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.subject.keywordPlus | CATIONIC PROTEIN | - |
dc.subject.keywordPlus | DISEASE-ACTIVITY | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | IL-31 | - |
dc.subject.keywordPlus | EXPRESSION | - |
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