Recent insights regarding the molecular basis of myeloproliferative neoplasms
DC Field | Value | Language |
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dc.contributor.author | Jang, Mi-Ae | - |
dc.contributor.author | Choi, Chul Won | - |
dc.date.accessioned | 2021-08-31T14:50:47Z | - |
dc.date.available | 2021-08-31T14:50:47Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 1226-3303 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/58408 | - |
dc.description.abstract | Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal disorders characterized by the overproduction of mature blood cells that have an increased risk of thrombosis and progression to acute myeloid leukemia. Next-generation sequencing studies have provided key insights regarding the molecular mechanisms of MPNs. MPN driver mutations in genes associated with the JAK-STAT pathway include JAK2 V617F, JAK2 exon 12 mutations and mutations in MPL, CALR, and CSF3R. Cooperating driver genes are also frequently detected and also mutated in other myeloid neoplasms; these driver genes are involved in epigenetic methylation, messenger RNA splicing, transcription regulation, and signal transduction. In addition, other genetic factors such as germline predisposition, order of mutation acquisition, and variant allele frequency also influence disease initiation and progression. This review summarizes the current understanding of the genetic basis of MPN, and demonstrates how molecular pathophysiology can improve both our understanding of MPN heterogeneity and clinical practice. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN ASSOC INTERNAL MEDICINE | - |
dc.subject | CHRONIC NEUTROPHILIC LEUKEMIA | - |
dc.subject | TYROSINE KINASE JAK2 | - |
dc.subject | THROMBOPOIETIN RECEPTOR | - |
dc.subject | POLYCYTHEMIA-VERA | - |
dc.subject | ESSENTIAL THROMBOCYTHEMIA | - |
dc.subject | MUTANT CALRETICULIN | - |
dc.subject | SOMATIC MUTATIONS | - |
dc.subject | CLONAL HEMATOPOIESIS | - |
dc.subject | ACTIVATING MUTATION | - |
dc.subject | CLINICAL PHENOTYPE | - |
dc.title | Recent insights regarding the molecular basis of myeloproliferative neoplasms | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Chul Won | - |
dc.identifier.doi | 10.3904/kjim.2019.317 | - |
dc.identifier.scopusid | 2-s2.0-85077896598 | - |
dc.identifier.wosid | 000505206100001 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF INTERNAL MEDICINE, v.35, no.1, pp.1 - 11 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.title | KOREAN JOURNAL OF INTERNAL MEDICINE | - |
dc.citation.volume | 35 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART002538397 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | CHRONIC NEUTROPHILIC LEUKEMIA | - |
dc.subject.keywordPlus | TYROSINE KINASE JAK2 | - |
dc.subject.keywordPlus | THROMBOPOIETIN RECEPTOR | - |
dc.subject.keywordPlus | POLYCYTHEMIA-VERA | - |
dc.subject.keywordPlus | ESSENTIAL THROMBOCYTHEMIA | - |
dc.subject.keywordPlus | MUTANT CALRETICULIN | - |
dc.subject.keywordPlus | SOMATIC MUTATIONS | - |
dc.subject.keywordPlus | CLONAL HEMATOPOIESIS | - |
dc.subject.keywordPlus | ACTIVATING MUTATION | - |
dc.subject.keywordPlus | CLINICAL PHENOTYPE | - |
dc.subject.keywordAuthor | Mutation | - |
dc.subject.keywordAuthor | Thrombocythemia | - |
dc.subject.keywordAuthor | essential | - |
dc.subject.keywordAuthor | Polycythemia vera | - |
dc.subject.keywordAuthor | Primary myelofibrosis | - |
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