The age-adjusted Charlson comorbidity index as a predictor of overall survival of surgically treated non-metastatic clear cell renal cell carcinoma
DC Field | Value | Language |
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dc.contributor.author | Kang, Ho Won | - |
dc.contributor.author | Kim, Sung Min | - |
dc.contributor.author | Kim, Won Tae | - |
dc.contributor.author | Yun, Seok Joong | - |
dc.contributor.author | Lee, Sang-Cheol | - |
dc.contributor.author | Kim, Wun-Jae | - |
dc.contributor.author | Hwang, Eu Chang | - |
dc.contributor.author | Kang, Seok Ho | - |
dc.contributor.author | Hong, Sung-Hoo | - |
dc.contributor.author | Chung, Jinsoo | - |
dc.contributor.author | Kwon, Tae Gyun | - |
dc.contributor.author | Kim, Hyeon Hoe | - |
dc.contributor.author | Kwak, Cheol | - |
dc.contributor.author | Byun, Seok-Soo | - |
dc.contributor.author | Kim, Yong-June | - |
dc.date.accessioned | 2021-08-31T14:52:10Z | - |
dc.date.available | 2021-08-31T14:52:10Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 0171-5216 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/58418 | - |
dc.description.abstract | Purpose No study has evaluated the prognostic impact of the age-adjusted Charlson comorbidity index (AACI) in those with renal cell carcinoma (RCC). This study aimed to evaluate the utility of the AACI for predicting long-term survival in patients with surgically treated non-metastatic clear cell RCC (ccRCC). Methods Data from 698 patients with non-metastatic ccRCC who underwent radical or partial nephrectomy as primary therapy from a multi-institutional Korean collaboration between 1988 and 2015 were retrospectively analyzed. Clinicopathological variables and survival outcomes of those with AACI scores <= 3 (n = 324), 4-5 (n = 292), and >= 6 (n = 82) were compared. Results Patients with a high AACI score were older and more likely to be female. They were also more likely to have diabetes or hypertension, a worse Eastern Cooperative Oncology Group performance status, and lower preoperative hemoglobin, albumin, serum calcium, and serum total cholesterol levels. Regarding pathologic features, a high AACI score was associated with advanced stage. Kaplan-Meier analyses revealed that AACI >= 6 was associated with shorter cancer-specific (log-rank test, P < 0.001) and overall survival (log-rank test, P < 0.001), but not with recurrence-free survival (log-rank test, P = 0.134). Multivariate Cox regression analyses identified an AACI score as an independent predictor of overall survival (hazard ratio, 6.870; 95% confidence interval, 2.049-23.031; P = 0.002). The AACI score was a better discriminator of overall survival than the Charlson comorbidity index score. Conclusions AACI scores may enable more tailored, individualized management strategies for patients with surgically treated non-metastatic ccRCC. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | CLINICAL-PRACTICE GUIDELINES | - |
dc.subject | IMPACT | - |
dc.subject | CANCER | - |
dc.subject | DIAGNOSIS | - |
dc.subject | OUTCOMES | - |
dc.subject | SURGERY | - |
dc.subject | SCORE | - |
dc.title | The age-adjusted Charlson comorbidity index as a predictor of overall survival of surgically treated non-metastatic clear cell renal cell carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Seok Ho | - |
dc.identifier.doi | 10.1007/s00432-019-03042-7 | - |
dc.identifier.scopusid | 2-s2.0-85074047721 | - |
dc.identifier.wosid | 000492209800001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, v.146, no.1, pp.187 - 196 | - |
dc.relation.isPartOf | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | - |
dc.citation.title | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | - |
dc.citation.volume | 146 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 187 | - |
dc.citation.endPage | 196 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | CLINICAL-PRACTICE GUIDELINES | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | SCORE | - |
dc.subject.keywordAuthor | Renal cell carcinoma | - |
dc.subject.keywordAuthor | Nephrectomy | - |
dc.subject.keywordAuthor | Comorbidity | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Survival | - |
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