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Neuroimaging in Randomized, Multi-Center Clinical Trials of Endovascular Treatment for Acute Ischemic Stroke: A Systematic Review

Authors
Suh, Chong HyunJung, Seung ChaiKim, ByungjunCho, Se JinWoo, Dong-CheolOh, Woo YongLee, Jong GuKim, Kyung Won
Issue Date
1월-2020
Publisher
KOREAN RADIOLOGICAL SOC
Keywords
Acute ischemic stroke; Endovascular treatment; Clinical trials; Neuroimaging; Systematic review
Citation
KOREAN JOURNAL OF RADIOLOGY, v.21, no.1, pp.42 - 57
Indexed
SCIE
SCOPUS
KCI
Journal Title
KOREAN JOURNAL OF RADIOLOGY
Volume
21
Number
1
Start Page
42
End Page
57
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/58435
DOI
10.3348/kjr.2019.0354
ISSN
1229-6929
Abstract
Appropriate use and analysis of neuroimaging techniques is an inevitable aspect of clinical trials for patients with acute ischemic stroke. Neuroimaging examinations were recently used to define the core eligibility criteria and outcomes in acute ischemic stroke research. Recent clinical trials for endovascular treatment in acute ischemic stroke have also demonstrated the efficacy or safety of endovascular treatment using various imaging modalities as well as clinical indices. Furthermore, independent imaging reviews and imaging core laboratory assessments are essential to manage and analyze imaging data in order to enhance the reliability of the outcomes. Therefore, we systematically reviewed the use of neuroimaging in recent randomized clinical trials for endovascular treatment of acute ischemic stroke in order to provide a thorough summary, which would serve as a resource guiding the use of appropriate imaging protocols and analyses in future clinical trials for acute ischemic stroke. This review will help researchers select appropriate imaging biomarkers among the various imaging protocols available and apply the selected type of imaging examination for each study in accordance with the academic purpose.
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