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Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation

Authors
Park, DoYeunLee, JaeseoChung, Justin J.Jung, YoungmeeKim, Soo Hyun
Issue Date
1월-2020
Publisher
ELSEVIER SCIENCE LONDON
Keywords
innervation-on-a-chip; integrated organ-on-a-chip; multiplexing; organ-on-chip; scaling rules; vascularization-on-a-chip
Citation
TRENDS IN BIOTECHNOLOGY, v.38, no.1, pp.99 - 112
Indexed
SCIE
SCOPUS
Journal Title
TRENDS IN BIOTECHNOLOGY
Volume
38
Number
1
Start Page
99
End Page
112
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/58447
DOI
10.1016/j.tibtech.2019.06.006
ISSN
0167-7799
Abstract
Organs-on-chips (OoCs) have attracted significant attention because they can be designed to mimic in vivo environments. Beyond constructing a single OoC, recent efforts have tried to integrate multiple OoCs to broaden potential applications such as disease modeling and drug discoveries. However, various challenges remain for integrating OoCs towards in vivo-like operation, such as incorporating various connections for integrating multiple OoCs. We review multiplexed OoCs and challenges they face: scaling, vascularization, and innervation. In our opinion, future OoCs will be constructed to have increased predictive power for in vivo phenomena and will ultimately become a mainstream tool for high quality biomedical and pharmaceutical research.
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Graduate School > KU-KIST Graduate School of Converging Science and Technology > 1. Journal Articles

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