Regional Arterial Spin Labeling Perfusion Defect Is Associated With Early Ischemic Recurrence in Patients With a Transient Ischemic Attack
DC Field | Value | Language |
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dc.contributor.author | Nam, Ki-Woong | - |
dc.contributor.author | Kim, Chi Kyung | - |
dc.contributor.author | Ko, Sang-Kae | - |
dc.contributor.author | Yoon, Byung-Woo | - |
dc.contributor.author | Yoo, Roh-Eul | - |
dc.contributor.author | Sohn, Chul-Ho | - |
dc.date.accessioned | 2021-08-31T14:57:55Z | - |
dc.date.available | 2021-08-31T14:57:55Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 0039-2499 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/58456 | - |
dc.description.abstract | Background and Purpose- With the lack of confirmatory examinations, the distinction of a transient ischemic attack (TIA) from various TIA-mimicking diseases is difficult, particularly in diffusion-weighted imaging (DWI)-negative TIAs. In this study, we aimed to evaluate the relationship between arterial spin labeling (ASL) perfusion defects and early ischemic recurrence (FU-DWI [+]) in patients with DWI-negative TIAs. Methods- We assessed consecutive patients with a DWI-negative TIA within 24 hours of symptom onset, who underwent both ASL images and follow-up magnetic resonance imaging during the acute period. As markers of the ASL images, we evaluated the ASL perfusion defects in each hemisphere. Arterial transit artifact (ATA) and intraarterial high-intensity signal (IAS) were also rated as markers of collateral status and blood stagnation due to large vessel occlusion, respectively. Results- Among the 136 patients with a DWI-negative TIA, 33 patients had FU-DWI (+) lesions in 36 hemispheres. In the multivariable analysis, ASL defects remained an independent predictor of FU-DWI (+) (adjusted odds ratio, 13.94 [95% CI, 5.77-33.70], P<0.001). In the evaluation of the interactive relationship between ASL defects and ATA/IAS, the (ASL [+] ATA [-]) group showed the highest frequencies of FU-DWI (+) events (55.6%) with the highest adjusted odds ratio values (adjusted odds ratio, 14.86 [95% CI, 5.63-39.24], P<0.001), indicating a negative synergistic effect between the ASL defects and ATA. Meanwhile, the (ASL [+] IAS [+]) group showed higher frequencies of FU-DWI (+) and higher adjusted odds ratio values than those of the (ASL [+] IAS [-]) and (ASL [-] IAS [-]) groups, indicating a positive synergistic effect. Conclusions- We demonstrated that ASL perfusion defects were associated with ipsilateral FU-DWI (+) in patients with a DWI-negative TIA. Furthermore, this association was enhanced with IASs and attenuated with ATAs. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | NEGATIVE DIFFUSION | - |
dc.subject | STROKE | - |
dc.subject | MRI | - |
dc.subject | OCCLUSION | - |
dc.subject | PREDICT | - |
dc.subject | LESION | - |
dc.subject | IDENTIFY | - |
dc.title | Regional Arterial Spin Labeling Perfusion Defect Is Associated With Early Ischemic Recurrence in Patients With a Transient Ischemic Attack | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chi Kyung | - |
dc.identifier.doi | 10.1161/STROKEAHA.119.026556 | - |
dc.identifier.scopusid | 2-s2.0-85077225625 | - |
dc.identifier.wosid | 000504225600041 | - |
dc.identifier.bibliographicCitation | STROKE, v.51, no.1, pp.186 - 192 | - |
dc.relation.isPartOf | STROKE | - |
dc.citation.title | STROKE | - |
dc.citation.volume | 51 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 186 | - |
dc.citation.endPage | 192 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | NEGATIVE DIFFUSION | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordPlus | OCCLUSION | - |
dc.subject.keywordPlus | PREDICT | - |
dc.subject.keywordPlus | LESION | - |
dc.subject.keywordPlus | IDENTIFY | - |
dc.subject.keywordAuthor | diffusion | - |
dc.subject.keywordAuthor | magnetic resonance imaging | - |
dc.subject.keywordAuthor | perfusion | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | transient ischemic attack | - |
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