Impact of age on thromboembolic events in patients with non-valvular atrial fibrillation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yun Gi | - |
dc.contributor.author | Choi, Jong-Il | - |
dc.contributor.author | Boo, Ki Yung | - |
dc.contributor.author | Kim, Do Young | - |
dc.contributor.author | Hong, Yeji | - |
dc.contributor.author | Kim, Min Sun | - |
dc.contributor.author | Lee, Kwang-No | - |
dc.contributor.author | Shim, Jaemin | - |
dc.contributor.author | Kim, Jin Seok | - |
dc.contributor.author | Kim, Young-Hoon | - |
dc.date.accessioned | 2021-08-31T15:03:31Z | - |
dc.date.available | 2021-08-31T15:03:31Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 0160-9289 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/58491 | - |
dc.description.abstract | BackgroundAge is a well-established risk factor for thromboembolic events in patients with atrial fibrillation (AF). However, the mechanism underlying the association between age and thromboembolic events in AF remains unknown. MethodsThe prognostic value of age as a risk factor for thromboembolic events was analyzed using data from the Korean National Health Insurance Service (NHIS). In a large-scale single-center registry, cardiac hemodynamic parameters were examined to elucidate the cause of increased risk of thromboembolic events in older patients. ResultsNHIS sample cohort data including 5896 patients with AF revealed that the risk of thromboembolic complication differed significantly according to age despite equal CHA(2)DS(2)-VASc score. In the registry of 2801 patients, age showed significant correlations with left atrium (LA) diameter, LA volume, E/e, pulmonary artery pressure, and LA appendage flow velocity. Older patients had a significantly higher prevalence of spontaneous echocontrast (odds ratio [OR] = 1.030; P<.001). Age (OR = 1.031; P<.001), E/e ' (OR = 1.065; P = .004), and LA appendage flow velocity (OR = .988; P = .009) were significant predictors for thromboembolic events in multivariate analyses. In data from the NHIS, CHA(2)DS(2)-VASc score did not outperform age to predict thromboembolic events. ConclusionsAge is a significant risk factor for thromboembolic events in patients with AF, and old age is associated with adverse cardiac hemodynamics. This study suggests that older patients with AF are at high risk of thromboembolic events regardless of CHA(2)DS(2)-VASc score. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | CHA(2)DS(2)-VASC SCORE | - |
dc.subject | RISK STRATIFICATION | - |
dc.subject | PREDICTING STROKE | - |
dc.subject | VALIDATION | - |
dc.subject | SCHEMES | - |
dc.title | Impact of age on thromboembolic events in patients with non-valvular atrial fibrillation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yun Gi | - |
dc.contributor.affiliatedAuthor | Choi, Jong-Il | - |
dc.contributor.affiliatedAuthor | Shim, Jaemin | - |
dc.contributor.affiliatedAuthor | Kim, Jin Seok | - |
dc.identifier.doi | 10.1002/clc.23293 | - |
dc.identifier.scopusid | 2-s2.0-85075363694 | - |
dc.identifier.wosid | 000496702600001 | - |
dc.identifier.bibliographicCitation | CLINICAL CARDIOLOGY, v.43, no.1, pp.78 - 85 | - |
dc.relation.isPartOf | CLINICAL CARDIOLOGY | - |
dc.citation.title | CLINICAL CARDIOLOGY | - |
dc.citation.volume | 43 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 78 | - |
dc.citation.endPage | 85 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | CHA(2)DS(2)-VASC SCORE | - |
dc.subject.keywordPlus | RISK STRATIFICATION | - |
dc.subject.keywordPlus | PREDICTING STROKE | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.subject.keywordPlus | SCHEMES | - |
dc.subject.keywordAuthor | age | - |
dc.subject.keywordAuthor | atrial fibrillation | - |
dc.subject.keywordAuthor | ischemic stroke | - |
dc.subject.keywordAuthor | thromboembolic complication | - |
dc.subject.keywordAuthor | transient ischemic attack | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.