Factors associated with obsessive-compulsive symptoms in people with epilepsy
DC Field | Value | Language |
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dc.contributor.author | Kim, Soo Jeong | - |
dc.contributor.author | Lee, Sang-Ahm | - |
dc.contributor.author | Ryu, Han Uk | - |
dc.contributor.author | Han, Su-Hyun | - |
dc.contributor.author | Lee, Gha-hyun | - |
dc.contributor.author | Jo, Kwang-Deog | - |
dc.contributor.author | Kim, Jung Bin | - |
dc.date.accessioned | 2021-08-31T15:07:30Z | - |
dc.date.available | 2021-08-31T15:07:30Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 1525-5050 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/58518 | - |
dc.description.abstract | Purpose: Obsessive-compulsive disorder (OCD) is a common but underrecognized psychiatric condition comorbid with epilepsy. We thus investigated clinical factors associated with obsessive-compulsive symptoms (OCS) in adults with epilepsy. Methods: This was a cross-sectional multicenter study in Republic of Korea. Obsessive-compulsive symptoms were assessed using the Obsessive-Compulsive Inventory-Revised (OCI-R). Clinical factors that were assessed included age, sex, seizure-related variables, and the number and use of antiepileptic drugs (AEDs) prescribed. Data were analyzed by stepwise linear regression and adjusted according to anxiety and depressive symptoms as assessed by Hospital Anxiety Depression Scale (HADS). Results: The study population comprised 221 adults with epilepsy (42.1% male, 39.7 +/- 11.9 years of age). The mean OCI-R score was 18.0 (standard deviation, 12.7), and an OCl-R score of >= 21 was obtained for 40.3% of the study sample. On a stepwise linear regression analysis, epilepsy severity, temporal lobe seizures, the use of topiramate, and the use of lamotrigine were identified as independent factors associated with OCl-R score after adjusting for anxiety according to the HADS. All factors except topiramate usage were positively associated with OCS. The total explained variance was 37.3%. Conclusions: Obsessive-compulsive symptoms are common in persons with epilepsy and are associated with severe epilepsy, temporal lobe seizures, and the use of topiramate and lamotrigine. Specifically, the use of lamotrigine may aggravate OCS, whereas the use of topiramate may have beneficial effects on OCS. (C) 2019 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | DOUBLE-BLIND | - |
dc.subject | TOPIRAMATE AUGMENTATION | - |
dc.subject | ILAE COMMISSION | - |
dc.subject | POSITION PAPER | - |
dc.subject | DISORDER | - |
dc.subject | LAMOTRIGINE | - |
dc.subject | CLASSIFICATION | - |
dc.subject | NEUROBIOLOGY | - |
dc.subject | DEPRESSION | - |
dc.subject | INVENTORY | - |
dc.title | Factors associated with obsessive-compulsive symptoms in people with epilepsy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Jung Bin | - |
dc.identifier.doi | 10.1016/j.yebeh.2019.106723 | - |
dc.identifier.scopusid | 2-s2.0-85075752035 | - |
dc.identifier.wosid | 000506868100040 | - |
dc.identifier.bibliographicCitation | EPILEPSY & BEHAVIOR, v.102 | - |
dc.relation.isPartOf | EPILEPSY & BEHAVIOR | - |
dc.citation.title | EPILEPSY & BEHAVIOR | - |
dc.citation.volume | 102 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Behavioral Sciences | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Behavioral Sciences | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | TOPIRAMATE AUGMENTATION | - |
dc.subject.keywordPlus | ILAE COMMISSION | - |
dc.subject.keywordPlus | POSITION PAPER | - |
dc.subject.keywordPlus | DISORDER | - |
dc.subject.keywordPlus | LAMOTRIGINE | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | NEUROBIOLOGY | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | INVENTORY | - |
dc.subject.keywordAuthor | Epilepsy | - |
dc.subject.keywordAuthor | Obsessive-compulsive disorder | - |
dc.subject.keywordAuthor | Depression | - |
dc.subject.keywordAuthor | Anxiety | - |
dc.subject.keywordAuthor | Lamotrigine | - |
dc.subject.keywordAuthor | Topiramate | - |
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