The Role of Acid Suppressants in the Prevention of Anticoagulant-Related Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis
DC Field | Value | Language |
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dc.contributor.author | Bang, Chang Seok | - |
dc.contributor.author | Joo, Moon Kyung | - |
dc.contributor.author | Kim, Byung-Wook | - |
dc.contributor.author | Kim, Joon Sung | - |
dc.contributor.author | Park, Chan Hyuk | - |
dc.contributor.author | Ahn, Ji Yong | - |
dc.contributor.author | Lee, Jeong Hoon | - |
dc.contributor.author | Lee, Bong Eun | - |
dc.contributor.author | Yang, Hyo-Joon | - |
dc.contributor.author | Cho, Yu Kyung | - |
dc.contributor.author | Park, Jae Myung | - |
dc.contributor.author | Kim, Beom Jin | - |
dc.contributor.author | Jung, Hye-Kyung | - |
dc.date.accessioned | 2021-08-31T15:15:26Z | - |
dc.date.available | 2021-08-31T15:15:26Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/58570 | - |
dc.description.abstract | Background/AIms: Although acid suppressants are widely used for the prevention or treatment of drug-induced upper gastrointestinal bleeding (GIB), evidence regarding the prevention of anticoagulant-related GIB is scarce. The aim of this study was to evaluate the protective effect of acid suppressants against anticoagulant-related GIB. Methods: A systematic review was conducted of studies that evaluated the protective effect of acid suppressants against anticoagulant-related GIB found in PubMed, the Cochrane library, Embase, and KoreaMed from the date of database inception to April 2018. Random effect model meta-analyses with sensitivity analyses were conducted. The methodological quality of each included publication was evaluated using the Risk of Bias Assessment Tool for Nonrandomized Studies. Publication bias was assessed. Results: In total, six nested case-control or cohort studies were identified and analyzed. Proton-pump inhibitors (PPI) had a protective effect against upper GIB in patients on dicumarinics (risk ratio [RR], 0.56; 95% confidence interval [CI], 0.38 to 0.83; I-2, 0%); however, the histamine-2 receptor antagonist did not have the same effect (RR, 0.97; 95% CI, 0.52 to 1.81; I-2, 0%). Acid suppressants did not have a protective effect against GIB in patients on dabigatran (hazard ratio, 0.78; 95% CI, 0.44 to 1.37; I-2, 81.8%). Conclusions: The protective effect of PPIs against dicumarinics-related upper GIB was clear, while there was no evidence supporting the protective effect of acid suppressants against dabigatran-related GIB. However, in the absence of randomized trials demonstrating a lack of bias, solid conclusions cannot be drawn. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | - |
dc.subject | PROTON PUMP INHIBITORS | - |
dc.subject | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | - |
dc.subject | ORAL ANTICOAGULANTS | - |
dc.subject | RISK | - |
dc.subject | ASSOCIATION | - |
dc.subject | WARFARIN | - |
dc.subject | REDUCE | - |
dc.subject | AGENTS | - |
dc.subject | BIAS | - |
dc.title | The Role of Acid Suppressants in the Prevention of Anticoagulant-Related Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Joo, Moon Kyung | - |
dc.identifier.doi | 10.5009/gnl19009 | - |
dc.identifier.wosid | 000507928400009 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, v.14, no.1, pp.57 - 66 | - |
dc.relation.isPartOf | GUT AND LIVER | - |
dc.citation.title | GUT AND LIVER | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 57 | - |
dc.citation.endPage | 66 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART002551938 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | PROTON PUMP INHIBITORS | - |
dc.subject.keywordPlus | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | - |
dc.subject.keywordPlus | ORAL ANTICOAGULANTS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | WARFARIN | - |
dc.subject.keywordPlus | REDUCE | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordPlus | BIAS | - |
dc.subject.keywordAuthor | Anticoagulants | - |
dc.subject.keywordAuthor | Acid suppressants | - |
dc.subject.keywordAuthor | Gastrointestinal hemorrhage | - |
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