Clerodane Diterpenoids Isolated from the Leaves of Casearia graveolens
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liu, Feng | - |
dc.contributor.author | Ma, Jun | - |
dc.contributor.author | Shi, Zhaoyu | - |
dc.contributor.author | Zhang, Qi | - |
dc.contributor.author | Wang, Huimei | - |
dc.contributor.author | Li, Dihua | - |
dc.contributor.author | Song, Zhaohui | - |
dc.contributor.author | Wang, Chunyan | - |
dc.contributor.author | Jin, Jin | - |
dc.contributor.author | Xu, Jing | - |
dc.contributor.author | Tuerhong, Muhetaer | - |
dc.contributor.author | Abudukeremu, Munira | - |
dc.contributor.author | Shuai, Ling | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Guo, Yuanqiang | - |
dc.date.accessioned | 2021-08-31T15:54:09Z | - |
dc.date.available | 2021-08-31T15:54:09Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/58899 | - |
dc.description.abstract | A phytochemical survey aiming to acquire pharmacologically active substances has resulted in the isolation of nine new clerodane diterpenoids, named graveospenes A-I (1-9), from the leaves of Casearia graveolens. Spectroscopic methods were employed to establish the structures with their absolute configurations being confirmed by ECD data analysis. A biological evaluation was performed, and compound 1 was found to be cytotoxic to both human lung cancer cells (A549) and human hepatocellular carcinoma cells (HepG2). A mechanism-of-action study on 1 revealed this compound to induce apoptosis of A549 cells and impede them at the G(0)/G(1) stage. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | ANTI-NEUROINFLAMMATORY AGENTS | - |
dc.subject | TWIGS | - |
dc.subject | BARK | - |
dc.subject | TERPENOIDS | - |
dc.title | Clerodane Diterpenoids Isolated from the Leaves of Casearia graveolens | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dongho | - |
dc.identifier.doi | 10.1021/acs.jnatprod.9b00515 | - |
dc.identifier.scopusid | 2-s2.0-85078382644 | - |
dc.identifier.wosid | 000510076700007 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.83, no.1, pp.36 - 44 | - |
dc.relation.isPartOf | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 83 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 36 | - |
dc.citation.endPage | 44 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ANTI-NEUROINFLAMMATORY AGENTS | - |
dc.subject.keywordPlus | TWIGS | - |
dc.subject.keywordPlus | BARK | - |
dc.subject.keywordPlus | TERPENOIDS | - |
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