Choosing Wisely": Apolipoprotein E Genetic Testing for the Diagnosis of Alzheimer's Disease in Dementia Clinics
DC Field | Value | Language |
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dc.contributor.author | Yang, Hyun Ju | - |
dc.contributor.author | Kang, Na Ri | - |
dc.contributor.author | Jung, Young Eun | - |
dc.contributor.author | Kim, Moon Doo | - |
dc.contributor.author | Jeong, Hyun Ghang | - |
dc.contributor.author | Lee, Tae Jin | - |
dc.contributor.author | Han, Ji Won | - |
dc.contributor.author | Kim, Ki Woong | - |
dc.contributor.author | Park, Joon Hyuk | - |
dc.date.accessioned | 2021-08-31T16:17:10Z | - |
dc.date.available | 2021-08-31T16:17:10Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/59084 | - |
dc.description.abstract | Background: Apolipoprotein E (APOE) epsilon 4 allele carriers have an increased risk of late-onset Alzheimer's disease (AD). However, in the "Choosing Wisely" campaign for avoiding unnecessary medical tests, treatments, and procedures, APOE genetic testing is not recommended as a predictive test for AD. Objective: The aim of this study was to investigate the potential value of APOE genetic testing in a specific clinical context. Methods: Subjects with poor performance in the Korean version of the Mini-Mental Status Examination for dementia screening (MMSE-DS) with a Z-score of less than -1.5 were recruited from the public health centers. All participants underwent APOE genetic testing. Family history of dementia (FHx) was confirmed if one or more first-degree relatives had dementia. Results: Among 349 subjects, 162 (46.4%) were diagnosed with AD. APOE epsilon 4 allele carriers had a much higher risk of AD in the group with FHx than in the group without FHx (OR = 15.81, 95% CI= 2.74-91.21 versus OR = 1.82, 95% CI= 1.00-3.27, z= 2.293, p = 0.011). The sensitivity, specificity, positive predictive value, and negative predictive value for the APOE epsilon 4 allele were 47.7%, 90.9%, 91.3%, and 46.5% in the group with FHx. Conclusion: It would be a wise choice to perform the APOE genetic testing for the diagnosis of AD in subjects with poor performance in a screening test and a family history of dementia. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | IOS PRESS | - |
dc.subject | RISK-FACTORS | - |
dc.subject | E GENOTYPE | - |
dc.subject | FAMILY-HISTORY | - |
dc.subject | KOREAN VERSION | - |
dc.subject | APOE GENOTYPE | - |
dc.subject | TYPE-4 ALLELE | - |
dc.subject | ASSOCIATION | - |
dc.subject | SPECIFICITY | - |
dc.subject | SENSITIVITY | - |
dc.subject | CONSORTIUM | - |
dc.title | Choosing Wisely": Apolipoprotein E Genetic Testing for the Diagnosis of Alzheimer's Disease in Dementia Clinics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeong, Hyun Ghang | - |
dc.identifier.doi | 10.3233/JAD-190983 | - |
dc.identifier.scopusid | 2-s2.0-85083878590 | - |
dc.identifier.wosid | 000579315200020 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ALZHEIMERS DISEASE, v.74, no.4, pp.1253 - 1260 | - |
dc.relation.isPartOf | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.citation.title | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.citation.volume | 74 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1253 | - |
dc.citation.endPage | 1260 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | E GENOTYPE | - |
dc.subject.keywordPlus | FAMILY-HISTORY | - |
dc.subject.keywordPlus | KOREAN VERSION | - |
dc.subject.keywordPlus | APOE GENOTYPE | - |
dc.subject.keywordPlus | TYPE-4 ALLELE | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | SPECIFICITY | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | CONSORTIUM | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | apolipoprotein genetic testing | - |
dc.subject.keywordAuthor | odds ratio | - |
dc.subject.keywordAuthor | sensitivity | - |
dc.subject.keywordAuthor | specificity | - |
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