Kidney-Targeted Cytosolic Delivery of siRNA Using a Small-Sized Mirror DNA Tetrahedron for Enhanced Potency
DC Field | Value | Language |
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dc.contributor.author | Thai, H.B.D. | - |
dc.contributor.author | Kim, K.-R. | - |
dc.contributor.author | Hong, K.T. | - |
dc.contributor.author | Voitsitskyi, T. | - |
dc.contributor.author | Lee, J.-S. | - |
dc.contributor.author | Mao, C. | - |
dc.contributor.author | Ahn, D.-R. | - |
dc.date.accessioned | 2021-08-31T19:21:30Z | - |
dc.date.available | 2021-08-31T19:21:30Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2374-7943 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/60744 | - |
dc.description.abstract | A proper intracellular delivery method with target tissue specificity is critical to utilize the full potential of therapeutic molecules including siRNAs while minimizing their side effects. Herein, we prepare four small-sized DNA tetrahedrons (sTds) by self-assembly of different sugar backbone-modified oligonucleotides and screened them to develop a platform for kidney-targeted cytosolic delivery of siRNA. An in vivo biodistribution study revealed the kidney-specific accumulation of mirror DNA tetrahedron (L-sTd). Low opsonization of L-sTd in serum appeared to avoid liver clearance and keep its size small enough to be filtered through the glomerular basement membrane (GBM). After GBM filtration, L-sTd could be delivered into tubular cells by endocytosis. The kidney preference and the tubular cell uptake property of the mirror DNA nanostructure could be successfully harnessed for kidney-targeted intracellular delivery of p53 siRNA to treat acute kidney injury (AKI) in mice. Therefore, L-sTd could be a promising platform for kidney-targeted cytosolic delivery of siRNA to treat renal diseases. © 2020 American Chemical Society. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | American Chemical Society | - |
dc.subject | Geometry | - |
dc.subject | Mammals | - |
dc.subject | Mirrors | - |
dc.subject | Oligonucleotides | - |
dc.subject | DNA nanostructures | - |
dc.subject | Glomerular basement membrane | - |
dc.subject | Intracellular delivery | - |
dc.subject | Modified oligonucleotides | - |
dc.subject | Renal disease | - |
dc.subject | Target tissues | - |
dc.subject | Therapeutic molecules | - |
dc.subject | Tubular cells | - |
dc.subject | DNA | - |
dc.title | Kidney-Targeted Cytosolic Delivery of siRNA Using a Small-Sized Mirror DNA Tetrahedron for Enhanced Potency | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, J.-S. | - |
dc.identifier.doi | 10.1021/acscentsci.0c00763 | - |
dc.identifier.scopusid | 2-s2.0-85096556737 | - |
dc.identifier.bibliographicCitation | ACS Central Science, v.6, no.12, pp.2250 - 2258 | - |
dc.relation.isPartOf | ACS Central Science | - |
dc.citation.title | ACS Central Science | - |
dc.citation.volume | 6 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2250 | - |
dc.citation.endPage | 2258 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | Geometry | - |
dc.subject.keywordPlus | Mammals | - |
dc.subject.keywordPlus | Mirrors | - |
dc.subject.keywordPlus | Oligonucleotides | - |
dc.subject.keywordPlus | DNA nanostructures | - |
dc.subject.keywordPlus | Glomerular basement membrane | - |
dc.subject.keywordPlus | Intracellular delivery | - |
dc.subject.keywordPlus | Modified oligonucleotides | - |
dc.subject.keywordPlus | Renal disease | - |
dc.subject.keywordPlus | Target tissues | - |
dc.subject.keywordPlus | Therapeutic molecules | - |
dc.subject.keywordPlus | Tubular cells | - |
dc.subject.keywordPlus | DNA | - |
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