Alterations in articular cartilage T2 star relaxation time following mechanical disorders: In vivo canine supraspinatus tendon resection models
DC Field | Value | Language |
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dc.contributor.author | Lee, D. | - |
dc.contributor.author | Hong, K.-T. | - |
dc.contributor.author | Lim, T.S. | - |
dc.contributor.author | Lee, E. | - |
dc.contributor.author | Lee, Y.H. | - |
dc.contributor.author | Park, J.S. | - |
dc.contributor.author | Kim, W. | - |
dc.contributor.author | Oh, J.H. | - |
dc.contributor.author | Choi, J.-A. | - |
dc.contributor.author | Song, Y. | - |
dc.date.accessioned | 2021-08-31T19:27:51Z | - |
dc.date.available | 2021-08-31T19:27:51Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1471-2474 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/60791 | - |
dc.description.abstract | Background: The role of altered joint mechanics on cartilage degeneration in in vivo models has not been studied successfully due to a lack of pre-injury information. We aimed 1) to develop an accurate in vivo canine model to measure the changes in joint loading and T2 star (T2*) relaxation time before and after unilateral supraspinatus tendon resections, and 2) to find the relationship between regional variations in articular cartilage loading patterns and T2*relaxation time distributions. Methods: Rigid markers were implanted in the scapula and humerus of tested dogs. The movement of the shoulder bones were measured by a motion tracking system during normal gaits. In vivo cartilage contact strain was measured by aligning 3D shoulder models with the motion tracking data. Articular cartilage T2*relaxation times were measured by quantitative MRI scans. Articular cartilage contact strain and T2*relaxation time were compared in the shoulders before and 3 months after the supraspinatus tendon resections. Results: Excellent accuracy and reproducibility were found in our in vivo contact strain measurements with less than 1% errors. Changes in articular cartilage contact strain exhibited similar patterns with the changes in the T2*relaxation time after resection surgeries. Regional changes in the articular cartilage T2*relaxation time exhibited positive correlations with regional contact strain variations 3 months after the supraspinatus resection surgeries. Conclusion: This is the first study to measure in vivo articular cartilage contact strains with high accuracy and reproducibility. Positive correlations between contact strain and T2*relaxation time suggest that the articular cartilage extracellular matrix may responds to mechanical changes in local areas. © 2020 The Author(s). | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BioMed Central | - |
dc.subject | adolescent | - |
dc.subject | animal experiment | - |
dc.subject | animal model | - |
dc.subject | Article | - |
dc.subject | articular cartilage | - |
dc.subject | cartilage thickness | - |
dc.subject | clinical effectiveness | - |
dc.subject | correlational study | - |
dc.subject | in vivo study | - |
dc.subject | mongrel dog | - |
dc.subject | musculoskeletal system parameters | - |
dc.subject | nonhuman | - |
dc.subject | nuclear magnetic resonance imaging | - |
dc.subject | relaxation time | - |
dc.subject | supraspinatus tendon resection | - |
dc.subject | tendon surgery | - |
dc.title | Alterations in articular cartilage T2 star relaxation time following mechanical disorders: In vivo canine supraspinatus tendon resection models | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Y. | - |
dc.identifier.doi | 10.1186/s12891-020-03447-3 | - |
dc.identifier.scopusid | 2-s2.0-85087474364 | - |
dc.identifier.bibliographicCitation | BMC Musculoskeletal Disorders, v.21, no.1 | - |
dc.relation.isPartOf | BMC Musculoskeletal Disorders | - |
dc.citation.title | BMC Musculoskeletal Disorders | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | adolescent | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | articular cartilage | - |
dc.subject.keywordPlus | cartilage thickness | - |
dc.subject.keywordPlus | clinical effectiveness | - |
dc.subject.keywordPlus | correlational study | - |
dc.subject.keywordPlus | in vivo study | - |
dc.subject.keywordPlus | mongrel dog | - |
dc.subject.keywordPlus | musculoskeletal system parameters | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | nuclear magnetic resonance imaging | - |
dc.subject.keywordPlus | relaxation time | - |
dc.subject.keywordPlus | supraspinatus tendon resection | - |
dc.subject.keywordPlus | tendon surgery | - |
dc.subject.keywordAuthor | Animal model | - |
dc.subject.keywordAuthor | Articular cartilage | - |
dc.subject.keywordAuthor | Biomechanics | - |
dc.subject.keywordAuthor | Magnetic resonance imaging | - |
dc.subject.keywordAuthor | Osteoarthritis | - |
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