Discovery of metabolic alterations in the serum of patients infected with Plasmodium spp. by high-resolution metabolomics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Na, Jinhyuk | - |
dc.contributor.author | Khan, Adnan | - |
dc.contributor.author | Kim, Jae Kwan | - |
dc.contributor.author | Wadood, Abdul | - |
dc.contributor.author | Choe, Young Lan | - |
dc.contributor.author | Walker, Douglas, I | - |
dc.contributor.author | Jones, Dean P. | - |
dc.contributor.author | Lim, Chae Seung | - |
dc.contributor.author | Park, Youngja Hwang | - |
dc.date.accessioned | 2021-08-31T19:42:08Z | - |
dc.date.available | 2021-08-31T19:42:08Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-12-23 | - |
dc.identifier.issn | 1573-3882 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/60885 | - |
dc.description.abstract | Introduction Despite the advances in diagnosis and treatment, malaria has still not been eradicated. Metabolic interactions between the host and Plasmodium may present novel targets for malaria control, but such interactions are yet to be deciphered. An exploration of metabolic interactions between humans and two Plasmodium species by high-resolution metabolomics may provide fundamental insights that can aid the development of a new strategy for the control of malaria. Objectives This study aimed at exploring the metabolic changes in the sera of patients infected with Plasmodium falciparum and Plasmodium vivax. Methods Uni- and multivariate metabolomic analyses were performed on the sera of four groups of patients, namely normal control (N, n = 100), P. falciparum-infected patients (PF, n = 21), P. vivax-infected patients (PV, n = 74), and non-malarial pyretic patients (Pyr, n = 25). Results Univariate and multivariate analyses of N, PF, and PV groups showed differential metabolic phenotypes and subsequent comparisons in pairs revealed significant features. Pathway enrichment test with significant features showed the affected pathways, namely glycolysis/gluconeogenesis for PF and retinol metabolism for PV. The metabolites belonging to the affected pathways included significantly low 2,3-diphosphoglycerate and glyceraldehyde-3-phosphate in the sera of PF. The sera of PV had significantly low levels of retinol but high levels of retinoic acid. Conclusion Our study reveals metabolic alterations induced by Plasmodium spp. in human serum and would serve as a milestone in the development of novel anti-malarial strategies. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | VITAMIN-A | - |
dc.subject | FALCIPARUM-MALARIA | - |
dc.subject | 2,3-DIPHOSPHOGLYCERATE | - |
dc.subject | PATHOGENESIS | - |
dc.subject | INFLAMMATION | - |
dc.subject | MEMBRANE | - |
dc.subject | BIOLOGY | - |
dc.subject | METLIN | - |
dc.title | Discovery of metabolic alterations in the serum of patients infected with Plasmodium spp. by high-resolution metabolomics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Youngja Hwang | - |
dc.identifier.doi | 10.1007/s11306-019-1630-2 | - |
dc.identifier.scopusid | 2-s2.0-85077038677 | - |
dc.identifier.wosid | 000512819100001 | - |
dc.identifier.bibliographicCitation | METABOLOMICS, v.16, no.1 | - |
dc.relation.isPartOf | METABOLOMICS | - |
dc.citation.title | METABOLOMICS | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | VITAMIN-A | - |
dc.subject.keywordPlus | FALCIPARUM-MALARIA | - |
dc.subject.keywordPlus | 2,3-DIPHOSPHOGLYCERATE | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | METLIN | - |
dc.subject.keywordAuthor | Malaria | - |
dc.subject.keywordAuthor | Plasmodium falciparum | - |
dc.subject.keywordAuthor | Plasmodium vivax | - |
dc.subject.keywordAuthor | Metabolomics | - |
dc.subject.keywordAuthor | LC-MS | - |
dc.subject.keywordAuthor | Biomarker | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.