Clinical Usefulness of Computational Modeling-Guided Persistent Atrial Fibrillation Ablation: Updated Outcome of Multicenter Randomized Study
DC Field | Value | Language |
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dc.contributor.author | Kim, In-Soo | - |
dc.contributor.author | Lim, Byounghyun | - |
dc.contributor.author | Shim, Jaemin | - |
dc.contributor.author | Hwang, Minki | - |
dc.contributor.author | Yu, Hee Tae | - |
dc.contributor.author | Kim, Tae-Noon | - |
dc.contributor.author | Uhm, Jae-Sun | - |
dc.contributor.author | Kim, Sung-Hwan | - |
dc.contributor.author | Joung, Boyoung | - |
dc.contributor.author | On, Young Keun | - |
dc.contributor.author | Oh, Seil | - |
dc.contributor.author | Oh, Yong-Seog | - |
dc.contributor.author | Nam, Gi-Byung | - |
dc.contributor.author | Lee, Moon-Hyoung | - |
dc.contributor.author | Shim, Eun Bo | - |
dc.contributor.author | Kim, Young-Noon | - |
dc.contributor.author | Pak, Hui-Nam | - |
dc.date.accessioned | 2021-08-31T20:22:07Z | - |
dc.date.available | 2021-08-31T20:22:07Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-12-17 | - |
dc.identifier.issn | 1664-042X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/60908 | - |
dc.description.abstract | Objective Catheter ablation of persistent atrial fibrillation (AF) is still challenging, no optimal extra-pulmonary vein lesion set is known. We previously reported the clinical feasibility of computational modeling-guided AF catheter ablation. Methods We randomly assigned 118 patients with persistent AF (77.8% men, age 60.8 +/- 9.9 years) to the computational modeling-guided ablation group (53 patients) and the empirical ablation group (55 patients) based on the operators' experience. For virtual ablation, four virtual linear and one electrogram-guided lesion sets were tested on patient heart computed tomogram-based models, and the lesion set with the fastest termination time was reported to the operator in the modeling-guided ablation group. The primary outcome was freedom from atrial tachyarrhythmias lasting longer than 30 s after a single procedure. Results During 31.5 +/- 9.4 months, virtual ablation procedures were available in 95.2% of the patients (108/118). Clinical recurrence rate was significantly lower after a modeling-guided ablation than after an empirical ablation (20.8 vs. 40.0%, log-rank p = 0.042). Modeling-guided ablation was independently associated with a better long-term rhythm outcome of persistent AF ablation (HR = 0.29 [0.12-0.69], p = 0.005). The rhythm outcome of the modeling-guided ablation showed better trends in males, non-obese patients with a less remodeled atrium (left atrial dimension < 50 mm), ejection fraction >= 50%, and those without hypertension or diabetes (p < 0.01). There were no significant differences between the groups for the total procedure time (p = 0.403), ablation time (p = 0.510), and major complication rate (p = 0.900). Conclusion Among patients with persistent AF, the computational modeling-guided ablation was superior to the empirical catheter ablation regarding the rhythm outcome. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.subject | CATHETER ABLATION | - |
dc.subject | FOLLOW-UP | - |
dc.subject | RECURRENCE | - |
dc.subject | MECHANISMS | - |
dc.title | Clinical Usefulness of Computational Modeling-Guided Persistent Atrial Fibrillation Ablation: Updated Outcome of Multicenter Randomized Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shim, Jaemin | - |
dc.identifier.doi | 10.3389/fphys.2019.01512 | - |
dc.identifier.scopusid | 2-s2.0-85077304982 | - |
dc.identifier.wosid | 000505191600001 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN PHYSIOLOGY, v.10 | - |
dc.relation.isPartOf | FRONTIERS IN PHYSIOLOGY | - |
dc.citation.title | FRONTIERS IN PHYSIOLOGY | - |
dc.citation.volume | 10 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Physiology | - |
dc.relation.journalWebOfScienceCategory | Physiology | - |
dc.subject.keywordPlus | CATHETER ABLATION | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | RECURRENCE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordAuthor | atrial fibrillation | - |
dc.subject.keywordAuthor | catheter ablation | - |
dc.subject.keywordAuthor | virtual ablation | - |
dc.subject.keywordAuthor | computational modeling | - |
dc.subject.keywordAuthor | recurrence | - |
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