Effect of simultaneous presence of anti-blood group A/B and -HLA antibodies on clinical outcomes in kidney transplantation across positive crossmatch: a nationwide cohort study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Hyunwook | - |
dc.contributor.author | Kim, Jee Yeon | - |
dc.contributor.author | Kim, Dong Hyun | - |
dc.contributor.author | Ko, Youngmin | - |
dc.contributor.author | Choi, Ji Yoon | - |
dc.contributor.author | Shin, Sung | - |
dc.contributor.author | Jung, Joo Hee | - |
dc.contributor.author | Kim, Young Hoon | - |
dc.contributor.author | Han, Duck Jong | - |
dc.contributor.author | Ahn, Curie | - |
dc.contributor.author | Chae, Dong Wan | - |
dc.contributor.author | Yang, Jaeseok | - |
dc.contributor.author | Choi, Bum Soon | - |
dc.contributor.author | Jung, Cheol Woong | - |
dc.contributor.author | Kim, Myung Soo | - |
dc.contributor.author | Kwon, Oh Jung | - |
dc.contributor.author | Park, Jae Berm | - |
dc.contributor.author | Kim, Yeong Hoon | - |
dc.contributor.author | Choi, SooJinNa | - |
dc.contributor.author | Han, Seung Yeup | - |
dc.contributor.author | Lee, Sang Ho | - |
dc.contributor.author | Jeong, Kyung Hwan | - |
dc.contributor.author | Kim, Seung Jung | - |
dc.contributor.author | Jeon, Jin Seok | - |
dc.contributor.author | Park, Yeon Ho | - |
dc.contributor.author | Roh, Young Nam | - |
dc.contributor.author | Lee, Jeong Joon | - |
dc.contributor.author | Lee, Kang Wook | - |
dc.contributor.author | Han, Seung Yeup | - |
dc.contributor.author | Kim, Chan Duck | - |
dc.contributor.author | Park, Jong Won | - |
dc.contributor.author | Kim, Joong Kyung | - |
dc.contributor.author | Lee, Dong Ryeol | - |
dc.contributor.author | Lee, Dong Won | - |
dc.contributor.author | Seong, Eun Young | - |
dc.contributor.author | Kong, Jin Min | - |
dc.contributor.author | Cho, Hong Rae | - |
dc.contributor.author | Park, Sung Kwang | - |
dc.contributor.author | Lee, Sam Yeol | - |
dc.contributor.author | Park, Jung Hwan | - |
dc.date.accessioned | 2021-08-31T21:46:30Z | - |
dc.date.available | 2021-08-31T21:46:30Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-12-03 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/60959 | - |
dc.description.abstract | ABO-incompatible (ABOi) and positive crossmatch (XM) kidney transplantation (KT) have been considered immunologically challenging. The present study analyzed the clinical outcomes in XM positive KT based on ABO incompatibility. We used data from the Korea Organ Transplantation Registry, a nationwide database, and a single-center registry. A total of 263 patients with positive XM were divided into an ABO compatible (ABOc) & XM positive (ABOc/XM+, n = 176) group and an ABOi & XM positive (ABOVXM+, n = 87) group. The overall rejection rate one year after KT was significantly higher in the ABOi/XM+ group than in the ABOc/XM+ group (P < 0.01). A total of four mortalities occurred, all in the ABOi/XM+ patients (P < 0.01). There were no differences in surgical complications or the occurrence of infection-related complications, including BK virus nephropathy. Multivariate analysis indicated that female vs. male (odds ratio (OR), 2.27; P= 0.03), DSA class I (MFI/1000) (OR, 1.10; P= 0.03), DSA class II (MFI/1000) (OR, 1.10; P < 0.01), and ABOi & XM+ status (OR, 2.38; P < 0.01) were significant risk factors for acute rejection during the year after transplantation. Overall graft survival was inferior in ABOi/XM+ patients than in ABOc/XM+ patients (P= 0.02). ABO incompatibility in XM-positive KT patients was found to be a significant risk factor for the development of rejection within one year after transplantation as well as for long-term graft survival. The anti-blood group A, B and anti-HLA antibodies may show synergistic activity. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | MEDIATED REJECTION | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | ABO | - |
dc.subject | RECIPIENTS | - |
dc.subject | BIOPSIES | - |
dc.title | Effect of simultaneous presence of anti-blood group A/B and -HLA antibodies on clinical outcomes in kidney transplantation across positive crossmatch: a nationwide cohort study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Cheol Woong | - |
dc.identifier.doi | 10.1038/s41598-019-54397-3 | - |
dc.identifier.wosid | 000500816100001 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.9 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | MEDIATED REJECTION | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | ABO | - |
dc.subject.keywordPlus | RECIPIENTS | - |
dc.subject.keywordPlus | BIOPSIES | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.