Degradation of tumour stromal hyaluronan by small extracellular vesicle-PH20 stimulates CD103(+) dendritic cells and in combination with PD-L1 blockade boosts anti-tumour immunity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Yeonsun | - |
dc.contributor.author | Kim, Yoon Kyoung | - |
dc.contributor.author | Kim, Gi Beom | - |
dc.contributor.author | Nam, Gi-Noon | - |
dc.contributor.author | Kim, Seong A. | - |
dc.contributor.author | Park, Yoon | - |
dc.contributor.author | Yang, Yoosoo | - |
dc.contributor.author | Kim, In-San | - |
dc.date.accessioned | 2021-08-31T22:08:54Z | - |
dc.date.available | 2021-08-31T22:08:54Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-12-01 | - |
dc.identifier.issn | 2001-3078 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/60987 | - |
dc.description.abstract | Highly accumulated hyaluronan (HA) not only provides a physiological barrier but also supports an immune-suppressive tumour microenvironment. High-molecular-weight (HMW)-HA inhibits the activation of immune cells and their access into tumour tissues, whereas, low-molecular-weight oligo-HA is known to potentially activate dendritic cells (DCs). In this paper, we investigated whether small extracellular vesicle (EVs)-PH20 hyaluronidase induces tumour HA degradation, which, in turn, activates DCs to promote anti-cancer immune responses. Informed by our previous work, we used a small EV carrying GPI-anchored PH20 hyaluronidase (Exo-PH20) that could deeply penetrate into tumour foci via HA degradation. We found that Exo-PH20-treatment successfully activates the maturation and migration of DCs in vivo, particularly CD103(+) DCs leading to the activation of tumour-specific CD8(+) T cells, which work together to inhibit tumour growth. Moreover, combination with anti-PD-L1 antibody provided potent tumour-specific CD8(+) T cell immune responses as well as elicited prominent tumour growth inhibition both in syngenic and spontaneous breast cancer models, and this anti-tumour immunity was durable. Together, these results present new insights for HA degradation by Exo-PH20, providing a better understanding of oligo HA-triggered immune responses to cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | ASSISTED CARBOHYDRATE ELECTROPHORESIS | - |
dc.subject | TOLL-LIKE RECEPTOR | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | CANCER PROGRESSION | - |
dc.subject | MICROENVIRONMENT | - |
dc.subject | IMMUNOTHERAPY | - |
dc.subject | OLIGOSACCHARIDES | - |
dc.subject | INFILTRATION | - |
dc.subject | EXPRESSION | - |
dc.title | Degradation of tumour stromal hyaluronan by small extracellular vesicle-PH20 stimulates CD103(+) dendritic cells and in combination with PD-L1 blockade boosts anti-tumour immunity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, In-San | - |
dc.identifier.doi | 10.1080/20013078.2019.1670893 | - |
dc.identifier.scopusid | 2-s2.0-85073213859 | - |
dc.identifier.wosid | 000487921100001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF EXTRACELLULAR VESICLES, v.8, no.1 | - |
dc.relation.isPartOf | JOURNAL OF EXTRACELLULAR VESICLES | - |
dc.citation.title | JOURNAL OF EXTRACELLULAR VESICLES | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | ASSISTED CARBOHYDRATE ELECTROPHORESIS | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTOR | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | CANCER PROGRESSION | - |
dc.subject.keywordPlus | MICROENVIRONMENT | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | OLIGOSACCHARIDES | - |
dc.subject.keywordPlus | INFILTRATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Extracellular vesicle | - |
dc.subject.keywordAuthor | hyaluronidase | - |
dc.subject.keywordAuthor | dendritic cell | - |
dc.subject.keywordAuthor | cancer immunotherapy | - |
dc.subject.keywordAuthor | hyaluronan | - |
dc.subject.keywordAuthor | immune checkpoint blockade | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.