MiR-195 and miR-497 suppress tumorigenesis in lung cancer by inhibiting SMURF2-induced TGF-beta receptor I ubiquitination
DC Field | Value | Language |
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dc.contributor.author | Chae, Dong-Kyu | - |
dc.contributor.author | Park, Jinyoung | - |
dc.contributor.author | Cho, Moonsoo | - |
dc.contributor.author | Ban, Eunmi | - |
dc.contributor.author | Jang, Mihue | - |
dc.contributor.author | Yoo, Young Sook | - |
dc.contributor.author | Kim, Eunice EunKyeong | - |
dc.contributor.author | Baik, Ja-Hyun | - |
dc.contributor.author | Song, Eun Joo | - |
dc.date.accessioned | 2021-08-31T22:39:32Z | - |
dc.date.available | 2021-08-31T22:39:32Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1574-7891 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/61348 | - |
dc.description.abstract | SMURF2 is a member of the HECT family of E3 ubiquitin ligases that have important roles as a negative regulator of transforming growth factor-beta (TGF-beta) signaling through ubiquitin-mediated degradation of TGF-beta receptor I. However, the regulatory mechanism of SMURF2 is largely unknown. In this study, we identified that micro(mi)R-195 and miR-497 putatively target SMURF2 using several target prediction databases. Both miR-195 and miR-497 bind to the 3 '-UTR of the SMURF2 mRNA and inhibit SMURF2 expression. Furthermore, miR-195 and miR-497 regulate SMURF2-dependent T beta RI ubiquitination and cause the activation of the TGF-beta signaling pathway in lung cancer cells. Upregulation of miR-195 and miR-497 significantly reduced cell viability and colony formation through the activation of TGF-beta signaling. Interestingly, miR-195 and miR-497 also reduced the invasion ability of lung cancer cells when cells were treated with TGF-beta 1. Subsequent in vivo studies in xenograft nude mice model revealed that miR-195 and miR-497 repress tumor growth. These findings demonstrate that miR-195 and miR-497 act as a tumor suppressor by suppressing ubiquitination-mediated degradation of TGF-beta receptors through SMURF2, and suggest that miR-195 and miR-497 are potential therapeutic targets for lung cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | DOWN-REGULATION | - |
dc.subject | BREAST-CANCER | - |
dc.subject | DEPENDENT DEGRADATION | - |
dc.subject | LIGASE SMURF2 | - |
dc.subject | GROWTH | - |
dc.subject | MICRORNA | - |
dc.subject | EXPRESSION | - |
dc.subject | METASTASIS | - |
dc.subject | INVASION | - |
dc.subject | PROLIFERATION | - |
dc.title | MiR-195 and miR-497 suppress tumorigenesis in lung cancer by inhibiting SMURF2-induced TGF-beta receptor I ubiquitination | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Baik, Ja-Hyun | - |
dc.identifier.doi | 10.1002/1878-0261.12581 | - |
dc.identifier.scopusid | 2-s2.0-85074927661 | - |
dc.identifier.wosid | 000495179400001 | - |
dc.identifier.bibliographicCitation | MOLECULAR ONCOLOGY, v.13, no.12, pp.2663 - 2678 | - |
dc.relation.isPartOf | MOLECULAR ONCOLOGY | - |
dc.citation.title | MOLECULAR ONCOLOGY | - |
dc.citation.volume | 13 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2663 | - |
dc.citation.endPage | 2678 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | DEPENDENT DEGRADATION | - |
dc.subject.keywordPlus | LIGASE SMURF2 | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | MICRORNA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordAuthor | lung cancer | - |
dc.subject.keywordAuthor | miR-195 | - |
dc.subject.keywordAuthor | miR-497 | - |
dc.subject.keywordAuthor | SMURF2 | - |
dc.subject.keywordAuthor | Transforming growth factor (TGF)-beta | - |
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