A Small Compound KJ-28d Enhances the Sensitivity of Non-Small Cell Lung Cancer to Radio- and Chemotherapy
DC Field | Value | Language |
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dc.contributor.author | Ryu, Hwani | - |
dc.contributor.author | Kim, Hyo Jeong | - |
dc.contributor.author | Song, Jie-Young | - |
dc.contributor.author | Hwang, Sang-Gu | - |
dc.contributor.author | Kim, Jae-Sung | - |
dc.contributor.author | Kim, Joon | - |
dc.contributor.author | Bui, Thi Hong Nhung | - |
dc.contributor.author | Choi, Hyun-Kyung | - |
dc.contributor.author | Ahn, Jiyeon | - |
dc.date.accessioned | 2021-08-31T22:42:43Z | - |
dc.date.available | 2021-08-31T22:42:43Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/61376 | - |
dc.description.abstract | We previously reported on a poly (ADP-ribose) polymerase (PARP) 1/2 inhibitor N-(3-(hydroxycarbamoyl)phenyl)carboxamide (designated KJ-28d), which increased the death of human ovarian cancer BRCA1-deficient SNU-251 cells. In the present study, we further investigated the antitumor activities of KJ-28d in BRCA-proficient non-small cell lung cancer (NSCLC) cells to expand the use of PARP inhibitors. KJ-28d significantly inhibited the growth of NSCLC cells in vitro and in vivo, and induced DNA damage and reactive oxygen species in A549 and H1299 cells. Combined treatment with KJ-28d and ionizing radiation led to increased DNA damage responses in A549 and H1299 cells compared to KJ-28d or ionizing radiation alone, resulting in apoptotic cell death. Moreover, the combination of KJ-28d plus a DNA-damaging therapeutic agent (carboplatin, cisplatin, paclitaxel, or doxorubicin) synergistically inhibited cell proliferation, compared to either drug alone. Taken together, the findings demonstrate the potential of KJ-28d as an effective anti-cancer therapeutic agent for BRCA-deficient and -proficient cancer cells. KJ-28d might have potential as an adjuvant when used in combination with radiotherapy or DNA-damaging agents, pending further investigations. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | DNA-DAMAGE | - |
dc.subject | POLYMERASE INHIBITION | - |
dc.subject | IN-VIVO | - |
dc.subject | COMBINATION | - |
dc.subject | ABT-888 | - |
dc.subject | PARP-1 | - |
dc.subject | REPAIR | - |
dc.subject | VELIPARIB | - |
dc.subject | EFFICACY | - |
dc.title | A Small Compound KJ-28d Enhances the Sensitivity of Non-Small Cell Lung Cancer to Radio- and Chemotherapy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Joon | - |
dc.identifier.doi | 10.3390/ijms20236026 | - |
dc.identifier.scopusid | 2-s2.0-85075928770 | - |
dc.identifier.wosid | 000504428300208 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.20, no.23 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 20 | - |
dc.citation.number | 23 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | POLYMERASE INHIBITION | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | ABT-888 | - |
dc.subject.keywordPlus | PARP-1 | - |
dc.subject.keywordPlus | REPAIR | - |
dc.subject.keywordPlus | VELIPARIB | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordAuthor | poly (ADP-ribose) polymerase inhibitor | - |
dc.subject.keywordAuthor | non-small cell lung cancer | - |
dc.subject.keywordAuthor | DNA damage | - |
dc.subject.keywordAuthor | radiotherapy | - |
dc.subject.keywordAuthor | chemotherapy | - |
dc.subject.keywordAuthor | combination therapy | - |
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