Silk Fibroin-Based Biomaterials for Biomedical Applications: A Review
- Authors
- Thang Phan Nguyen; Quang Vinh Nguyen; Van-Huy Nguyen; Thu-Ha Le; Vu Quynh Nga Huynh; Vo, Dai-Viet N.; Quang Thang Trinh; Kim, Soo Young; Quyet Van Le
- Issue Date
- 12월-2019
- Publisher
- MDPI
- Keywords
- silk fibroin; drug delivery; biologics delivery; wound healing; bone regeneration
- Citation
- POLYMERS, v.11, no.12
- Indexed
- SCIE
SCOPUS
- Journal Title
- POLYMERS
- Volume
- 11
- Number
- 12
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/61435
- DOI
- 10.3390/polym11121933
- ISSN
- 2073-4360
- Abstract
- Since it was first discovered, thousands of years ago, silkworm silk has been known to be an abundant biopolymer with a vast range of attractive properties. The utilization of silk fibroin (SF), the main protein of silkworm silk, has not been limited to the textile industry but has been further extended to various high-tech application areas, including biomaterials for drug delivery systems and tissue engineering. The outstanding mechanical properties of SF, including its facile processability, superior biocompatibility, controllable biodegradation, and versatile functionalization have allowed its use for innovative applications. In this review, we describe the structure, composition, general properties, and structure-properties relationship of SF. In addition, the methods used for the fabrication and modification of various materials are briefly addressed. Lastly, recent applications of SF-based materials for small molecule drug delivery, biological drug delivery, gene therapy, wound healing, and bone regeneration are reviewed and our perspectives on future development of these favorable materials are also shared.
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Collections - College of Engineering > Department of Materials Science and Engineering > 1. Journal Articles
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