The potential role of exosomes derived from ovarian cancer cells for diagnostic and therapeutic approaches
- Authors
- Yang, Changwon; Kim, Hee Seung; Song, Gwonhwa; Lim, Whasun
- Issue Date
- Dec-2019
- Publisher
- WILEY
- Keywords
- biomarker; exosome; microenvironment; microRNA; ovarian cancer cells
- Citation
- JOURNAL OF CELLULAR PHYSIOLOGY, v.234, no.12, pp.21493 - 21503
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CELLULAR PHYSIOLOGY
- Volume
- 234
- Number
- 12
- Start Page
- 21493
- End Page
- 21503
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/61477
- DOI
- 10.1002/jcp.28905
- ISSN
- 0021-9541
- Abstract
- Most patients with ovarian cancer (OC) are diagnosed at the advanced stages due to the absence of appropriate early diagnostic markers. Thus, OC is a gynecological disease with a low-survival rate. Exosomes are extracellular vesicles that are widely being considered as mediators for the noninvasive diagnosis of OC. Exosomes are expected to aid in the effective diagnosis of OC because they carry components, such as RNAs, proteins, and lipids, the compositions of which vary depending on the pathological characteristics of the patient. In this review, we document the methods that have been developed to detect exosomes and their components in OC. We also assess the potential biomarkers contained in exosomes that could be clinically useful, such as proteins, microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and phospholipids. Moreover, we described the role played by exosomes in the tumor microenvironment and in OC angiogenesis, migration, and tumor growth. Various types of cells in the tumor microenvironment, including macrophages, fibroblasts, and mesenchymal stem cells (MSCs), interact directly with exosomes and promote or inhibit the progression of OC. Therefore, we summarize the studies that have suggested a therapeutic approach to OC using exosomes. Collectively, understanding the mechanism of exosome-based OC progression would broaden our knowledge regarding the diagnosis and therapy of OC.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.