An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report
DC Field | Value | Language |
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dc.contributor.author | Gao, Man | - |
dc.contributor.author | Pang, Hui | - |
dc.contributor.author | Kim, Young Mi | - |
dc.contributor.author | Lu, Xianglan | - |
dc.contributor.author | Wang, Xianfu | - |
dc.contributor.author | Lee, Jiyun | - |
dc.contributor.author | Wang, Mingwei | - |
dc.contributor.author | Meng, Fanzheng | - |
dc.contributor.author | Li, Shibo | - |
dc.date.accessioned | 2021-08-31T22:53:59Z | - |
dc.date.available | 2021-08-31T22:53:59Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 1792-1074 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/61485 | - |
dc.description.abstract | Translocation (9;11)(p21.3;q23.3) is one of the most common lysine methyltransferase 2A (KMT2A)-rearrangements in de novo and therapy-related acute myeloid leukemia (AML). Numerous in vitro and in vivo studies have demonstrated that the KMT2A/MLLT3 super elongation complex subunit (MLLT3) fusion gene on the derivative chromosome 11 serves a crucial role in leukemogenesis. Trisomy 9 as a secondary chromosome change in patients with t(9;11) is relatively rare. The present study reported a unique case of AML with a chromosome 9 trisomy secondary to t(9;11)(p21.3;q23.3) through the cytogenetic analysis of leukemic blood and bone marrow. Further characterization with fluorescence in situ hybridization and array comparative genomic hybridization analysis revealed that this extra chromosome 9 was either a copy of normal chromosome 9 or a derivative chromosome 9. Conversely with the previously reported favorable outcome of AML patients with t(9;11)(p21.3;q23.3), in the present study, the cells with only translocation persisted, whereas the cells with an extra chromosome 9 disappeared following initial chemotherapy. With this unique case, the present study hypothesized that the extra chromosome 9 could serve a crucial role in AML disease progression and contribute to cellular sensitivity to chemotherapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | MLL RECOMBINOME | - |
dc.subject | DE-NOVO | - |
dc.subject | STEM-CELLS | - |
dc.subject | T(9/11) | - |
dc.subject | GENE | - |
dc.subject | TRANSLOCATIONS | - |
dc.subject | IDENTIFICATION | - |
dc.subject | NEOPLASMS | - |
dc.subject | ONCOGENE | - |
dc.subject | FUSION | - |
dc.title | An extra chromosome 9 derived from either a normal chromosome 9 or a derivative chromosome 9 in a patient with acute myeloid leukemia positive for t(9;11)(p21.3;q23.3): A case report | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jiyun | - |
dc.identifier.doi | 10.3892/ol.2019.11035 | - |
dc.identifier.scopusid | 2-s2.0-85076285466 | - |
dc.identifier.wosid | 000505576300118 | - |
dc.identifier.bibliographicCitation | ONCOLOGY LETTERS, v.18, no.6, pp.6725 - 6731 | - |
dc.relation.isPartOf | ONCOLOGY LETTERS | - |
dc.citation.title | ONCOLOGY LETTERS | - |
dc.citation.volume | 18 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 6725 | - |
dc.citation.endPage | 6731 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | MLL RECOMBINOME | - |
dc.subject.keywordPlus | DE-NOVO | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | T(9/11) | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | TRANSLOCATIONS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | NEOPLASMS | - |
dc.subject.keywordPlus | ONCOGENE | - |
dc.subject.keywordPlus | FUSION | - |
dc.subject.keywordAuthor | acute myeloid leukemia | - |
dc.subject.keywordAuthor | trisomy 9 | - |
dc.subject.keywordAuthor | t(9 | - |
dc.subject.keywordAuthor | 11)(p21 | - |
dc.subject.keywordAuthor | 3 | - |
dc.subject.keywordAuthor | q23 | - |
dc.subject.keywordAuthor | 3) | - |
dc.subject.keywordAuthor | disease progression | - |
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