Chemical Constituents from the Aerial Parts of Agastache rugosa and Their Inhibitory Activities on Prostaglandin E-2 Production in Lipopolysaccharide-Treated RAW 264.7 Macrophages
DC Field | Value | Language |
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dc.contributor.author | Seo, Young H. | - |
dc.contributor.author | Kang, Shin-Young | - |
dc.contributor.author | Shin, Ji-Sun | - |
dc.contributor.author | Ryu, Seung M. | - |
dc.contributor.author | Lee, A. Y. | - |
dc.contributor.author | Choi, Goya | - |
dc.contributor.author | Moon, Byeong C. | - |
dc.contributor.author | Jang, Dae-Sik | - |
dc.contributor.author | Shim, Sang H. | - |
dc.contributor.author | Lee, Dongho | - |
dc.contributor.author | Lee, Kyung-Tae | - |
dc.contributor.author | Lee, Jun | - |
dc.date.accessioned | 2021-08-31T22:54:52Z | - |
dc.date.available | 2021-08-31T22:54:52Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.issn | 0163-3864 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/61494 | - |
dc.description.abstract | A new flavone glucoside, acacetin-7-O-(3 ''-O-acety1-6 ''-O-malonyl)-beta-D-glucopyranoside (1), two new phenolic glucosides, (3R,7R)-tuberonic acid-12-O-[6'-O-(E)feruloyl]-beta-D-glucopyranoside (14) and salicylic acid-2-O-[6'-O-(E)-feruloyl]-beta-D-n-glucopyranoside (15), and two new phenylpropanoid glucosides, chavicol-1-O-(6'-O-methylmalonyl)-beta-D-glucopyranoside (17) and chavicol-1-O-(6'-O-acetyl)-beta-D-glucopyranoside(18), as well as 26 known compounds, 2-13, 16, and 19-31, were isolated from the aerial parts of Agastache rugose. The structures of the new compounds were established by spectroscopic/spectrometric methods such as HRESIMS, NMR, and ECD. The anti-inflammatory effect of the isolated compounds was evaluated by measuring their inhibitory activities on prostaglandin E-2 (PGE(2)) in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. New compounds 1, 15, 17, and 18 inhibited LPS-induced PGE2 production with IC50 values of 16.8 +/- 0.8, 33.9 +/- 4.8, 14.3 +/- 2.1, and 48.8 +/- 4.4 mu M, respectively. Compounds 5, 7, 9-11, 13, 19, 20, 22, and 27-30 showed potent inhibitory activities with IC50 values of 1.7-8.4 mu M. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | ESSENTIAL OIL | - |
dc.subject | ANTIOXIDANT | - |
dc.subject | KUNTZE | - |
dc.subject | GLYCOSIDES | - |
dc.subject | GLUCOSIDE | - |
dc.subject | XINJIANG | - |
dc.subject | ACACETIN | - |
dc.subject | CULTURES | - |
dc.subject | OXIDASE | - |
dc.subject | FLOWER | - |
dc.title | Chemical Constituents from the Aerial Parts of Agastache rugosa and Their Inhibitory Activities on Prostaglandin E-2 Production in Lipopolysaccharide-Treated RAW 264.7 Macrophages | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dongho | - |
dc.identifier.doi | 10.1021/acs.jnatprod.9b00697 | - |
dc.identifier.scopusid | 2-s2.0-85075445014 | - |
dc.identifier.wosid | 000505629000019 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NATURAL PRODUCTS, v.82, no.12, pp.3379 - 3385 | - |
dc.relation.isPartOf | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.title | JOURNAL OF NATURAL PRODUCTS | - |
dc.citation.volume | 82 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 3379 | - |
dc.citation.endPage | 3385 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Plant Sciences | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Plant Sciences | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ESSENTIAL OIL | - |
dc.subject.keywordPlus | ANTIOXIDANT | - |
dc.subject.keywordPlus | KUNTZE | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.subject.keywordPlus | GLUCOSIDE | - |
dc.subject.keywordPlus | XINJIANG | - |
dc.subject.keywordPlus | ACACETIN | - |
dc.subject.keywordPlus | CULTURES | - |
dc.subject.keywordPlus | OXIDASE | - |
dc.subject.keywordPlus | FLOWER | - |
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