Inhibition of androgen receptor can decrease fat metabolism by decreasing carnitine palmitoyltransferase I levels in skeletal muscles of trained mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jisu | - |
dc.contributor.author | Park, Jonghoon | - |
dc.contributor.author | Kim, Nahyun | - |
dc.contributor.author | Park, Hun-young | - |
dc.contributor.author | Lim, Kiwon | - |
dc.date.accessioned | 2021-08-31T23:01:04Z | - |
dc.date.available | 2021-08-31T23:01:04Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-11-27 | - |
dc.identifier.issn | 1743-7075 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/61539 | - |
dc.description.abstract | Background Androgen hormone levels are strongly associated with obesity in adult mammals, especially with advanced age. We investigated androgen receptor inhibition on fat metabolism and long-chain fatty acid (LCFA) transport proteins in skeletal muscle during exercise. Methods Male ICR mice were randomly divided into three groups: CON (control), EX (exercise), and EXIN (exercise + androgen receptor inhibition). EX and EXIN groups were trained on a treadmill five times a week. After 4 weeks, the fat metabolism of each group was measured using open-circuit calorimetry during 1 hour of exercise. After the metabolism measurement, the expression levels of LCFA transport proteins (FAT/CD36, CPTI) were analyzed in skeletal muscle. Results Weight gain and final body weight were significantly lower in the EX group than in either the CON or EXIN groups. Conversely, food intake was significantly higher in the EX group than it was in the CON and EXIN groups. The total weight (CON; 2.07 +/- 0.6, EX; 1.64 +/- 0.2, EXIN; 1.95 +/- 0.2) of the abdominal adipose tissue were significantly lower in the EX group than in the CON and EXIN groups (P < 0.05). However, there was no different between the CON and EXIN group. Oxygen uptake and fat oxidation during exercise tended to be lower (12%) in the EXIN group than in the EX group. Total fat oxidation in the EXIN group was significantly lower during the initial 20-min (P < 0.003) and 40-min (P < 0.041) phases compared to that in the EX group. In addition, the level of FAT/CD36 protein in the EX and EXIN groups was approximately double that in the CON group (P < 0.001, P < 0.001). CPTI expression in the EX group was higher than that in the EX group (P < 0.0069) as well as in the CON group. Conclusion Exercise training increases the expression of LCFA transport proteins (FAT/CD36, CPTI). Blocking androgen receptors can decreases the expression of CPTI in the skeletal muscle, which reduces fat metabolism. Thus, reducing sex hormones or suppressing the sensitivity of AR receptors can inhibit energy efficiency and fat metabolism by suppressing CPTI. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | ACID TRANSPORT PROTEINS | - |
dc.subject | EXERCISE PERFORMANCE | - |
dc.subject | LIPID-METABOLISM | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | DIHYDROTESTOSTERONE | - |
dc.subject | TESTOSTERONE | - |
dc.subject | EXPRESSION | - |
dc.subject | INSIGHTS | - |
dc.subject | INSULIN | - |
dc.subject | OBESITY | - |
dc.title | Inhibition of androgen receptor can decrease fat metabolism by decreasing carnitine palmitoyltransferase I levels in skeletal muscles of trained mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Jonghoon | - |
dc.identifier.doi | 10.1186/s12986-019-0406-z | - |
dc.identifier.scopusid | 2-s2.0-85075718531 | - |
dc.identifier.wosid | 000499456300001 | - |
dc.identifier.bibliographicCitation | NUTRITION & METABOLISM, v.16, no.1 | - |
dc.relation.isPartOf | NUTRITION & METABOLISM | - |
dc.citation.title | NUTRITION & METABOLISM | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | ACID TRANSPORT PROTEINS | - |
dc.subject.keywordPlus | EXERCISE PERFORMANCE | - |
dc.subject.keywordPlus | LIPID-METABOLISM | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | DIHYDROTESTOSTERONE | - |
dc.subject.keywordPlus | TESTOSTERONE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INSIGHTS | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordAuthor | FAT | - |
dc.subject.keywordAuthor | CD36 | - |
dc.subject.keywordAuthor | CPTI | - |
dc.subject.keywordAuthor | Androgen hormone | - |
dc.subject.keywordAuthor | Fat metabolism | - |
dc.subject.keywordAuthor | LCFA transport protein | - |
dc.subject.keywordAuthor | Androgen receptor | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.