NLRP3 negatively regulates Treg differentiation through Kpna2-mediated nuclear translocation
DC Field | Value | Language |
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dc.contributor.author | Park, Su-Ho | - |
dc.contributor.author | Ham, Sunyoung | - |
dc.contributor.author | Lee, Arim | - |
dc.contributor.author | Moller, Andreas | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.date.accessioned | 2021-08-31T23:02:15Z | - |
dc.date.available | 2021-08-31T23:02:15Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-11-22 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/61549 | - |
dc.description.abstract | Na?ve CD4(+) T cells in the periphery differentiate into regulatory T cells (Tregs) in which Foxp3 is expressed for their suppressive function. NLRP3, a pro-inflammatory molecule, is known to be involved in inflammasome activation associated with several diseases. Recently, the expression of NLRP3 in CD4(+) T cells, as well as in myeloid cells, has been described; however, a role of T cell?intrinsic NLRP3 in Treg differentiation remains unknown. Here, we report that NLRP3 impeded the expression of Foxp3 independent of inflammasome activation in Tregs. NLRP3-deficient mice elevate Treg generation in various organs in the de novo pathway. NLRP3 deficiency increased the amount and suppressive activity of Treg populations, whereas NLRP3 overexpression reduced Foxp3 expression and Treg abundance. Importantly, NLRP3 interacted with Kpna2 and translocated to the nucleus from the cytoplasm under Treg-polarizing conditions. Taken together, our results identify a novel role for NLRP3 as a new negative regulator of Treg differentiation, mediated via its interaction with Kpna2 for nuclear translocation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.subject | LEUCINE-RICH REPEAT | - |
dc.subject | FOXP3 EXPRESSION | - |
dc.subject | INFLAMMASOME | - |
dc.subject | PROTEIN | - |
dc.subject | CELLS | - |
dc.subject | ACTIVATION | - |
dc.subject | PYROPTOSIS | - |
dc.subject | MECHANISM | - |
dc.title | NLRP3 negatively regulates Treg differentiation through Kpna2-mediated nuclear translocation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Sung | - |
dc.identifier.doi | 10.1074/jbc.RA119.010545 | - |
dc.identifier.scopusid | 2-s2.0-85075578495 | - |
dc.identifier.wosid | 000504206800021 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.294, no.47, pp.17951 - 17961 | - |
dc.relation.isPartOf | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 294 | - |
dc.citation.number | 47 | - |
dc.citation.startPage | 17951 | - |
dc.citation.endPage | 17961 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | LEUCINE-RICH REPEAT | - |
dc.subject.keywordPlus | FOXP3 EXPRESSION | - |
dc.subject.keywordPlus | INFLAMMASOME | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PYROPTOSIS | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordAuthor | NLRP3 | - |
dc.subject.keywordAuthor | nuclear translocation | - |
dc.subject.keywordAuthor | T-cell biology | - |
dc.subject.keywordAuthor | cell differentiation | - |
dc.subject.keywordAuthor | forkhead box P3 (FOXP3) | - |
dc.subject.keywordAuthor | protein-protein interaction | - |
dc.subject.keywordAuthor | gene knockout | - |
dc.subject.keywordAuthor | transfection | - |
dc.subject.keywordAuthor | Western blot | - |
dc.subject.keywordAuthor | immunosuppression | - |
dc.subject.keywordAuthor | Inflammasome-independent pathway | - |
dc.subject.keywordAuthor | Kpna2 | - |
dc.subject.keywordAuthor | negative regulator | - |
dc.subject.keywordAuthor | Treg differentiation | - |
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