Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions
DC Field | Value | Language |
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dc.contributor.author | Song, Juhyun | - |
dc.contributor.author | Park, Dae Won | - |
dc.contributor.author | Moon, Sungwoo | - |
dc.contributor.author | Cho, Han-Jin | - |
dc.contributor.author | Park, Jong Hak | - |
dc.contributor.author | Seok, Hyeri | - |
dc.contributor.author | Choi, Won Seok | - |
dc.date.accessioned | 2021-08-31T23:32:44Z | - |
dc.date.available | 2021-08-31T23:32:44Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-11-12 | - |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/61903 | - |
dc.description.abstract | Background This study investigated the clinical value of interleukin-6 (IL-6), pentraxin 3 (PTX3), and procalcitonin (PCT) in patients with sepsis and septic shock diagnosed according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). Methods Serum levels of IL-6, PTX3, and PCT were measured in 142 enrolled subjects (51 with sepsis, 46 with septic shock, and 45 as controls). Follow-up IL-6 and PTX3 levels were measured in patients with initial septic shock within 24 h of hospital discharge. Optimal cut-off values were determined for sepsis and septic shock, and prognostic values were evaluated. Results Serum IL-6 levels could discriminate sepsis (area under the curve [AUC], 0.83-0.94, P < 0.001; cut-off value, 52.60 pg/mL, 80.4% sensitivity, 88.9% specificity) from controls and could distinguish septic shock (AUC, 0.71-0.89; cut-off value, 348.92 pg/mL, 76.1% sensitivity, 78.4% specificity) from sepsis. Twenty-eight-day mortality was significantly higher in the group with high IL-6 (>= 348.92 pg/mL) than in the group with low IL-6 (< 348.92 pg/mL) (P = 0.008). IL-6 was an independent risk factor for 28-day mortality among overall patients (hazard ratio, 1.0004; 95% confidence interval, 1.0003-1.0005; p = 0.024). In septic shock patients, both the initial and follow-up PTX3 levels were consistently significantly higher in patients who died than in those who recovered (initial p = 0.004; follow-up P < 0.001). Conclusions The diagnostic and prognostic value of IL-6 was superior to those of PTX3 and PCT for sepsis and septic shock. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | C-REACTIVE PROTEIN | - |
dc.subject | INTERNATIONAL CONSENSUS DEFINITIONS | - |
dc.subject | CRITICALLY ILL PATIENTS | - |
dc.subject | SURVIVING SEPSIS | - |
dc.subject | INNATE IMMUNITY | - |
dc.subject | MARKER | - |
dc.subject | CARE | - |
dc.subject | INFLAMMATION | - |
dc.subject | BIOMARKERS | - |
dc.subject | GUIDELINES | - |
dc.title | Diagnostic and prognostic value of interleukin-6, pentraxin 3, and procalcitonin levels among sepsis and septic shock patients: a prospective controlled study according to the Sepsis-3 definitions | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Juhyun | - |
dc.contributor.affiliatedAuthor | Park, Dae Won | - |
dc.contributor.affiliatedAuthor | Moon, Sungwoo | - |
dc.contributor.affiliatedAuthor | Cho, Han-Jin | - |
dc.contributor.affiliatedAuthor | Park, Jong Hak | - |
dc.contributor.affiliatedAuthor | Seok, Hyeri | - |
dc.contributor.affiliatedAuthor | Choi, Won Seok | - |
dc.identifier.doi | 10.1186/s12879-019-4618-7 | - |
dc.identifier.scopusid | 2-s2.0-85074926119 | - |
dc.identifier.wosid | 000497667000004 | - |
dc.identifier.bibliographicCitation | BMC INFECTIOUS DISEASES, v.19, no.1 | - |
dc.relation.isPartOf | BMC INFECTIOUS DISEASES | - |
dc.citation.title | BMC INFECTIOUS DISEASES | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.subject.keywordPlus | C-REACTIVE PROTEIN | - |
dc.subject.keywordPlus | INTERNATIONAL CONSENSUS DEFINITIONS | - |
dc.subject.keywordPlus | CRITICALLY ILL PATIENTS | - |
dc.subject.keywordPlus | SURVIVING SEPSIS | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | MARKER | - |
dc.subject.keywordPlus | CARE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | BIOMARKERS | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordAuthor | Interleukin-6 | - |
dc.subject.keywordAuthor | Pentraxin 3 | - |
dc.subject.keywordAuthor | Procalcitonin | - |
dc.subject.keywordAuthor | Sepsis | - |
dc.subject.keywordAuthor | Septic shock | - |
dc.subject.keywordAuthor | Emergency department | - |
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