Efficacy of Low Dose Proton Pump Inhibitor-Based Therapy to Eradicate Helicobacter pylori in Patients with Subtotal Gastrectomy
DC Field | Value | Language |
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dc.contributor.author | Kim, Dongwoo | - |
dc.contributor.author | Jung, Sung Woo | - |
dc.contributor.author | Lee, Dong-won | - |
dc.contributor.author | Lee, Chang Min | - |
dc.contributor.author | Kim, Seung Young | - |
dc.contributor.author | Hyun, Jong Jin | - |
dc.contributor.author | Jung, Young Kul | - |
dc.contributor.author | Koo, Ja Seol | - |
dc.contributor.author | Yim, Hyung Joon | - |
dc.contributor.author | Lee, Sang Woo | - |
dc.date.accessioned | 2021-09-01T01:15:14Z | - |
dc.date.available | 2021-09-01T01:15:14Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/62002 | - |
dc.description.abstract | Proton pump inhibitor (PPI)-based therapy is standard to eradicate Helicobacter pylori (H. pylori). Gastric acidity is lowered after gastrectomy because of bile reflux and impaired mechanism of acid secretion. Therefore, low-dose PPI may be effective for H. pylori eradication in the remnant stomach after gastrectomy. In this study, we compared the efficacy of low-dose PPI with standard double-dose PPI to eradicate H. pylori in patients who underwent subtotal gastrectomy. A total of 145 patients who were treated for eradication after gastrectomy was analyzed. They were treated with PPI-based triple regimen (PPI, clarithromycin and amoxicillin) for 14 days. We compared the eradication rate in the low-dose PPI group (lansoprazole 15 mg once daily) with that in the standard double-dose PPI group (lansoprazole 30 mg twice daily). The H. pylori eradication rate was 79.1% in the low-dose PPI group and 85.3% in the standard double-dose group; the difference was not significant statistically (p = 0.357). In the multivariate analysis, low-dose PPI (odds ratio (OR) = 1.79, 95% confidence interval (CI), 0.68-4.69) was not associated with eradication failure, while Billroth II anastomosis (OR = 4.45, 85% CI, 1.23-16.2) was significantly associated with eradication failure. Low-dose PPI-based triple regimen was as effective as standard double-dose PPI-based regimen for H. pylori eradication in patients with subtotal gastrectomy. Further study is needed to confirm the effect of low-dose PPI on H. pylori eradication in patients with gastrectomy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | GASTRIC-CANCER | - |
dc.subject | BILLROTH-I | - |
dc.subject | INFECTION | - |
dc.subject | GUIDELINES | - |
dc.subject | RISK | - |
dc.subject | PH | - |
dc.title | Efficacy of Low Dose Proton Pump Inhibitor-Based Therapy to Eradicate Helicobacter pylori in Patients with Subtotal Gastrectomy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Sung Woo | - |
dc.contributor.affiliatedAuthor | Lee, Chang Min | - |
dc.contributor.affiliatedAuthor | Kim, Seung Young | - |
dc.contributor.affiliatedAuthor | Hyun, Jong Jin | - |
dc.contributor.affiliatedAuthor | Jung, Young Kul | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seol | - |
dc.contributor.affiliatedAuthor | Yim, Hyung Joon | - |
dc.contributor.affiliatedAuthor | Lee, Sang Woo | - |
dc.identifier.doi | 10.3390/jcm8111933 | - |
dc.identifier.wosid | 000502294400176 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.8, no.11 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 11 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | GASTRIC-CANCER | - |
dc.subject.keywordPlus | BILLROTH-I | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | PH | - |
dc.subject.keywordAuthor | Helicobacter pylori | - |
dc.subject.keywordAuthor | eradication | - |
dc.subject.keywordAuthor | proton pump inhibitor | - |
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