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pH-Triggered Silk Fibroin/Alginate Structures Fabricated in Aqueous Two-Phase System

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dc.contributor.authorPark, DoYeun-
dc.contributor.authorCheng, Jie-
dc.contributor.authorPark, Jong Bo-
dc.contributor.authorShin, Sungchul-
dc.contributor.authorLee, Sang-Hoon-
dc.contributor.authorHong, Byung Hee-
dc.contributor.authorKim, Soo Hyun-
dc.contributor.authorHyun, Jinho-
dc.contributor.authorYang, Chaoyong-
dc.date.accessioned2021-09-01T01:18:37Z-
dc.date.available2021-09-01T01:18:37Z-
dc.date.created2021-06-19-
dc.date.issued2019-11-
dc.identifier.issn2373-9878-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/62024-
dc.description.abstractAn aqueous two-phase system (ATPS) is a water-in-water biphasic system, which is generally formed by two incompatible polymers. Recently, considerable effort has been dedicated to search for new ATPS polymer pairs to further expand ATPS's applications. In this paper, a new ATPS system based on silk fibroin (SF) and alginate is introduced. A phase diagram was established to show the critical concentrations for the formation of an SF/alginate ATPS. The present system is sensitive to pH stimulus and transformed from an ATPS into a single-phasic system as pH increases above similar to 9.5. Circular dichroism, fluorescence emission spectra, hydrodynamic diameter, and zeta-potential data together indicate that the SF chains undergo a dramatic extension as pH is increased, which is the reason underlying the pH-triggered phase transition. As feasible applications of this biphasic system, compartmentalized multiplex immunoassay, controlled encapsulation and release, and hierarchical fiber fabrication were demonstrated using the SF/alginate ATPS.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherAMER CHEMICAL SOC-
dc.subjectALGINATE-
dc.subjectFIBERS-
dc.subjectPURIFICATION-
dc.subjectMICROFIBERS-
dc.subjectMECHANISM-
dc.subjectFIBROIN-
dc.subjectSIZE-
dc.titlepH-Triggered Silk Fibroin/Alginate Structures Fabricated in Aqueous Two-Phase System-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Soo Hyun-
dc.identifier.doi10.1021/acsbiomaterials.9b01216-
dc.identifier.scopusid2-s2.0-85073143376-
dc.identifier.wosid000496344800036-
dc.identifier.bibliographicCitationACS BIOMATERIALS SCIENCE & ENGINEERING, v.5, no.11, pp.5897 - 5905-
dc.relation.isPartOfACS BIOMATERIALS SCIENCE & ENGINEERING-
dc.citation.titleACS BIOMATERIALS SCIENCE & ENGINEERING-
dc.citation.volume5-
dc.citation.number11-
dc.citation.startPage5897-
dc.citation.endPage5905-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalWebOfScienceCategoryMaterials Science, Biomaterials-
dc.subject.keywordPlusALGINATE-
dc.subject.keywordPlusFIBERS-
dc.subject.keywordPlusPURIFICATION-
dc.subject.keywordPlusMICROFIBERS-
dc.subject.keywordPlusMECHANISM-
dc.subject.keywordPlusFIBROIN-
dc.subject.keywordPlusSIZE-
dc.subject.keywordAuthoraqueous two-phase system-
dc.subject.keywordAuthorsilk fibroin-
dc.subject.keywordAuthoralginate-
dc.subject.keywordAuthorcompartmentalized multiplex immunoassay-
dc.subject.keywordAuthorcontrolled release-
dc.subject.keywordAuthorbiomimicking hierarchical fiber-
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