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The Potential Utility of Aripiprazole Augmentation for Major Depressive Disorder with Mixed Features Specifier: A Retrospective Study

Authors
Han, ChangsuWang, Sheng-MinBahk, Won-MyongLee, Soo-JungPatkar, Ashwin A.Masand, Prakash S.Pae, Chi-Un
Issue Date
11월-2019
Publisher
KOREAN COLL NEUROPSYCHOPHARMACOLOGY
Keywords
Aripiprazole; Depressive disorder; Mixed specifier; Effectiveness; Tolerability
Citation
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, v.17, no.4, pp.495 - 502
Indexed
SCIE
SCOPUS
KCI
Journal Title
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
Volume
17
Number
4
Start Page
495
End Page
502
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/62029
DOI
10.9758/cpn.2019.17.4.495
ISSN
1738-1088
Abstract
Objective: The present study aimed to observe potential benefit of aripiprazole augmentation in the treatment of major depressive disorder with mixed specifier (MDDM) in naturalistic treatment setting. Methods: Data were collected from MDDM patients using a retrospective chart review for 8 weeks (week -8 and week 0) in routine practice. All patients were on current antidepressants upon starting of aripiprazole. Patients were treated without restriction of doses of aripiprazole. The primary endpoint was the mean change of Montgomery-Asberg Depression Rating Scale (MADRS) total scores along with various secondary endpoint measures. Results: In total 38 patients were analyzed. The changes of MADRS, Clinical Global Impression (CGI)-severity, Young Mania Rating Scale, Sheehan Disability Scale, and CGI-clinical benefit total scores from baseline to the endpoint were -7.1, -0.8, -4.9, -4.1, and -3.6, respectively (all p < 0.0001). At the endpoint, the responder and remitter rates by MADRS score criteria were approximately 32% and 21%, respectively. Conclusion: The present findings have clearly shown the effectiveness and tolerability of aripiprazole augmentation for MDDM patients in routine practice. The present study warrants subsequent, adequately-powered, well-controlled studies for generalizability near future.
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