Berberine Ameliorates Brain Inflammation in Poloxamer 407-Induced Hyperlipidemic Rats
DC Field | Value | Language |
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dc.contributor.author | Kim, Mia | - |
dc.contributor.author | Kim, Tae-Woon | - |
dc.contributor.author | Kim, Chang-Ju | - |
dc.contributor.author | Shin, Mal-Soon | - |
dc.contributor.author | Hong, Minha | - |
dc.contributor.author | Park, Hye-Sang | - |
dc.contributor.author | Park, Sang-Seo | - |
dc.date.accessioned | 2021-09-01T01:21:39Z | - |
dc.date.available | 2021-09-01T01:21:39Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 2093-4777 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/62054 | - |
dc.description.abstract | Purpose: Hyperlipidemia, which promotes the development of atherosclerosis, ischemic stroke, and other forms of brain injury, can be induced by poloxamer-407. Berberine is a primary pharmacological active component of Coptidis Rhizoma that has a number of therapeutic activities. This study investigated the effects of berberine on poloxamer-407-induced brain inflammation by evaluating its effects on short-term memory, cell proliferation, inflammation, and apoptosis in the hippocampus. Methods: To induce hyperlipidemia in a rat model, 500 mg/kg of poloxamer-407 was injected intraperitoneally. Berberine was orally administered to the rats in the berberine-treated groups once a day for 4 weeks. The step-down task avoidance task was performed to measure short-term memory. An analysis of serum lipids, immunohistochemistry for 5-bromo-2'-deoxyuridine, glial fibrillary acidic protein (GAP), and ionized calcium-binding adapter molecule 1 (Ibal) in the dentate gyrus, and western blot analysis for Bax, Bcl-2, and cytochrome c in the hippocampus were performed. Results: In hyperlipidemic rats, berberine reduced the levels of triglycerides, total cholesterol, and low-density lipoprotein cholesterol and increased the level of high-density lipoprotein cholesterol in hyperlipidemic rats. Berberine also increased cell proliferation and short-term memory, as well as decreasing the expression of GFAP, Ibal, Bax, and cytochrorne c and increasing Bcl-2 expression. Conclusions: Berberine treatment improved short-term memory in hyperlipidemia by increasing neuronal proliferation and inhibiting neuronal apoptosis. Berberine treatment also improved lipid metabolism. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN CONTINENCE SOC | - |
dc.subject | TREADMILL EXERCISE | - |
dc.subject | MOTOR FUNCTION | - |
dc.subject | APOPTOSIS | - |
dc.subject | MEMORY | - |
dc.subject | KINASE | - |
dc.subject | ATHEROSCLEROSIS | - |
dc.subject | HIPPOCAMPUS | - |
dc.subject | MECHANISMS | - |
dc.subject | PATHWAY | - |
dc.subject | PROTEIN | - |
dc.title | Berberine Ameliorates Brain Inflammation in Poloxamer 407-Induced Hyperlipidemic Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Shin, Mal-Soon | - |
dc.identifier.doi | 10.5213/inj.1938216.108 | - |
dc.identifier.scopusid | 2-s2.0-85076131893 | - |
dc.identifier.wosid | 000500297600008 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL NEUROUROLOGY JOURNAL, v.23, pp.S102 - S110 | - |
dc.relation.isPartOf | INTERNATIONAL NEUROUROLOGY JOURNAL | - |
dc.citation.title | INTERNATIONAL NEUROUROLOGY JOURNAL | - |
dc.citation.volume | 23 | - |
dc.citation.startPage | S102 | - |
dc.citation.endPage | S110 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002527010 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | TREADMILL EXERCISE | - |
dc.subject.keywordPlus | MOTOR FUNCTION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordAuthor | Hyperlipidemia | - |
dc.subject.keywordAuthor | Berberine | - |
dc.subject.keywordAuthor | Poloxamer | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Glial fibrillary acidic protein | - |
dc.subject.keywordAuthor | Ibal | - |
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