Practical effectiveness of re-irradiation with or without surgery for locoregional recurrence of rectal cancer: A meta-analysis and systematic review
DC Field | Value | Language |
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dc.contributor.author | Lee, Jeongshim | - |
dc.contributor.author | Kim, Chul Yong | - |
dc.contributor.author | Koom, Woong Sub | - |
dc.contributor.author | Rim, Chai Hong | - |
dc.date.accessioned | 2021-09-01T01:48:07Z | - |
dc.date.available | 2021-09-01T01:48:07Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-11 | - |
dc.identifier.issn | 0167-8140 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/62129 | - |
dc.description.abstract | Background and purpose: Re-irradiation might yield local control (LC) or palliation for locoregionally recurrent rectal cancer (LRRC), but iatrogenic complications are a possible hindrance. We aimed to evaluate the efficacy of re-irradiation to determine optimal treatment of LRRC. Methods: We performed a systematic review of PubMed, MEDLINE, Cochrane Library, and Embase. Results: A total of 17 studies involving 744 patients with LRRC were included; median OS ranging from 10 to 45 months (median: 24.5 months). Pooled 1-, 2-, and 3-year OS rates for all patients were 76.1%, 49.1%, and 38.3%, respectively. For patients who underwent re-irradiation and surgery (OP group), these pooled rates were 85.9%, 71.8%, and 51.7%, respectively. For patients who underwent re-irradiation but not surgery (non-OP group), pooled 1-, 2-, and 3-year OS rates were 63.5%, 34.2%, and 23.8%, respectively. The OS difference between both groups was significant for all 3 years (P < 0.05). Pooled 1-, 2-, and 3-year LC rates for the OP group were 84.4%, 63.8%, and 46.9%, and for the non-OP group were 72.0%, 54.8%, and 44.6%, respectively, without significant differences. Pooled grade > 3 acute and late complication rates were 11.7% and 25.5% in the OP and non-OP groups, respectively. Patients who underwent surgery had a higher risk of grade > 3 late complications (odds ratio: 6.39). Pooled symptomatic palliation rate was 75.2%. Conclusions: Re-irradiation with or without surgery for LRRC showed oncologic and palliative efficacy. Salvage treatment including re-irradiation and surgery showed higher survival, but the late complication was significantly increased with concomitant surgery. (C) 2019 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | TOTAL MESORECTAL EXCISION | - |
dc.subject | STEREOTACTIC BODY RADIOTHERAPY | - |
dc.subject | LOCALLY RECURRENT | - |
dc.subject | PREOPERATIVE RADIOTHERAPY | - |
dc.subject | MULTIMODALITY TREATMENT | - |
dc.subject | SURGICAL RESECTION | - |
dc.subject | COLORECTAL-CANCER | - |
dc.subject | PELVIC RECURRENCE | - |
dc.subject | POOLED ANALYSIS | - |
dc.subject | HYPERTHERMIA | - |
dc.title | Practical effectiveness of re-irradiation with or without surgery for locoregional recurrence of rectal cancer: A meta-analysis and systematic review | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chul Yong | - |
dc.contributor.affiliatedAuthor | Rim, Chai Hong | - |
dc.identifier.doi | 10.1016/j.radonc.2019.05.021 | - |
dc.identifier.scopusid | 2-s2.0-85066478593 | - |
dc.identifier.wosid | 000491905000003 | - |
dc.identifier.bibliographicCitation | RADIOTHERAPY AND ONCOLOGY, v.140, pp.10 - 19 | - |
dc.relation.isPartOf | RADIOTHERAPY AND ONCOLOGY | - |
dc.citation.title | RADIOTHERAPY AND ONCOLOGY | - |
dc.citation.volume | 140 | - |
dc.citation.startPage | 10 | - |
dc.citation.endPage | 19 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | TOTAL MESORECTAL EXCISION | - |
dc.subject.keywordPlus | STEREOTACTIC BODY RADIOTHERAPY | - |
dc.subject.keywordPlus | LOCALLY RECURRENT | - |
dc.subject.keywordPlus | PREOPERATIVE RADIOTHERAPY | - |
dc.subject.keywordPlus | MULTIMODALITY TREATMENT | - |
dc.subject.keywordPlus | SURGICAL RESECTION | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | PELVIC RECURRENCE | - |
dc.subject.keywordPlus | POOLED ANALYSIS | - |
dc.subject.keywordPlus | HYPERTHERMIA | - |
dc.subject.keywordAuthor | Rectal cancer | - |
dc.subject.keywordAuthor | Recurrence | - |
dc.subject.keywordAuthor | Re-irradiation | - |
dc.subject.keywordAuthor | Surgery | - |
dc.subject.keywordAuthor | Complication | - |
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