Excessive daytime sleepiness and topographic expansion of Lewy pathology
DC Field | Value | Language |
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dc.contributor.author | Abbott, Robert D. | - |
dc.contributor.author | Ross, G. Webster | - |
dc.contributor.author | Duda, John E. | - |
dc.contributor.author | Shin, Chol | - |
dc.contributor.author | Uyehara-Lock, Janeh. | - |
dc.contributor.author | Masaki, Kamal H. | - |
dc.contributor.author | Launer, Lenore J. | - |
dc.contributor.author | White, Lon R. | - |
dc.contributor.author | Tanner, Caroline M. | - |
dc.contributor.author | Petrovitch, Helen | - |
dc.date.accessioned | 2021-09-01T04:23:59Z | - |
dc.date.available | 2021-09-01T04:23:59Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-10-08 | - |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/62533 | - |
dc.description.abstract | Objective While excessive daytime sleepiness (EDS) can predate the clinical diagnosis of Parkinson disease (PD), associations with underlying PD pathogenesis are unknown. Our objective is to determine if EDS is related to brain Lewy pathology (LP), a marker of PD pathogenesis, using clinical assessments of EDS with postmortem follow-up. Methods Identification of LP was based on staining for alpha-synuclein in multiple brain regions in a sample of 211 men. Data on EDS were collected at clinical examinations from 1991 to 1999 when participants were aged 72-97 years. Results Although EDS was more common in the presence vs absence of LP (p = 0.034), the association became stronger in neocortical regions. When LP was limited to the olfactory bulb, brainstem, and basal forebrain (Braak stages 1-4), frequency of EDS was 10% (4/40) vs 17.5% (20/114) in decedents without LP (p = 0.258). In contrast, compared to the absence of LP, EDS frequency doubled (36.7% [11/30], p = 0.023) when LP reached the anterior cingulate gyrus, insula mesocortex, and midfrontal, midtemporal, and inferior parietal neocortex (Braak stage 5). With further infiltration into the primary motor and sensory neocortices (Braak stage 6), EDS frequency increased threefold (51.9% [14/27], p < 0.001). Findings were similar across sleep-related features and persisted after adjustment for age and other covariates, including the removal of PD and dementia with Lewy bodies. Conclusions The association between EDS and PD includes relationships with extensive topographic LP expansion. The neocortex could be especially vulnerable to adverse relationships between sleep disorders and aggregation of misfolded alpha-synuclein and LP formation. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | CORONARY-HEART-DISEASE | - |
dc.subject | JAPANESE-AMERICAN MEN | - |
dc.subject | PARKINSONS-DISEASE | - |
dc.subject | CARDIOVASCULAR-DISEASE | - |
dc.subject | LATE-LIFE | - |
dc.subject | DISORDERS | - |
dc.subject | DEMENTIA | - |
dc.subject | STROKE | - |
dc.subject | HAWAII | - |
dc.subject | CALIFORNIA | - |
dc.title | Excessive daytime sleepiness and topographic expansion of Lewy pathology | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Abbott, Robert D. | - |
dc.contributor.affiliatedAuthor | Shin, Chol | - |
dc.identifier.doi | 10.1212/WNL.0000000000008241 | - |
dc.identifier.wosid | 000512608400002 | - |
dc.identifier.bibliographicCitation | NEUROLOGY, v.93, no.15, pp.E1425 - E1432 | - |
dc.relation.isPartOf | NEUROLOGY | - |
dc.citation.title | NEUROLOGY | - |
dc.citation.volume | 93 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | E1425 | - |
dc.citation.endPage | E1432 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | CORONARY-HEART-DISEASE | - |
dc.subject.keywordPlus | JAPANESE-AMERICAN MEN | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | LATE-LIFE | - |
dc.subject.keywordPlus | DISORDERS | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordPlus | HAWAII | - |
dc.subject.keywordPlus | CALIFORNIA | - |
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