The impact of body weight and diabetes on new-onset atrial fibrillation: a nationwide population based study
DC Field | Value | Language |
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dc.contributor.author | Kim, Yun Gi | - |
dc.contributor.author | Han, Kyung-Do | - |
dc.contributor.author | Choi, Jong-Il | - |
dc.contributor.author | Boo, Ki Yung | - |
dc.contributor.author | Kim, Do Young | - |
dc.contributor.author | Oh, Suk-Kyu | - |
dc.contributor.author | Lee, Kwang-No | - |
dc.contributor.author | Shim, Jaemin | - |
dc.contributor.author | Kim, Jin Seok | - |
dc.contributor.author | Kim, Young-Hoon | - |
dc.date.accessioned | 2021-09-01T04:46:42Z | - |
dc.date.available | 2021-09-01T04:46:42Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-10-01 | - |
dc.identifier.issn | 1475-2840 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/62579 | - |
dc.description.abstract | Background Being obese or underweight, and having diabetes are important risk factors for new-onset atrial fibrillation (AF). However, it is unclear whether there is any interaction between body weight and diabetes in regard to development of new-onset AF. We aimed to evaluate the role of body weight status and various stage of diabetes on new-onset AF. Methods This was a nationwide population based study using National Health Insurance Service (NHIS) data. A total of 9,797,418 patients who underwent national health check-ups were analyzed. Patients were classified as underweight [body mass index (BMI) < 18.5], normal reference group (18.5 <= BMI < 23.0), upper normal (23.0 <= BMI < 25.0), overweight (25.0 <= BMI < 30.0), or obese (BMI >= 30.0) based on BMI. Diabetes were categorized as non-diabetic, impaired fasting glucose (IFG), new-onset diabetes, diabetes < 5 years, and diabetes >= 5 years. Primary outcome end point was new-onset AF. New-onset AF was defined as one inpatient or two outpatient records of International Classification of Disease, Tenth Revision (ICD-10) codes in patients without prior AF diagnosis. Results During 80,130,161 patient*years follow-up, a total of 196,136 new-onset AF occurred. Obese [hazard ration (HR) = 1.327], overweight (HR = 1.123), upper normal (HR = 1.040), and underweight (HR = 1.055) patients showed significantly increased risk of new-onset AF compared to the normal reference group. Gradual escalation in the risk of new-onset AF was observed along with advancing diabetic stage. Body weight status and diabetes were independently associated with new-onset AF and at the same time, had synergistic effects on the risk of new-onset AF with obese diabetic patients having the highest risk (HR = 1.823). Conclusions Patients with obesity, overweight, underweight, and diabetes had significantly increased risk of new-onset AF. Body weight status and diabetes had synergistic effects on the risk of new-onset AF. The risk of new-onset AF increased gradually with advancing diabetic stage. This study suggests that maintaining optimal body weight and glucose homeostasis might prevent new-onset AF. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | CATHETER ABLATION | - |
dc.subject | FOLLOW-UP | - |
dc.subject | INDEPENDENT RISK | - |
dc.subject | OBESITY | - |
dc.subject | MANAGEMENT | - |
dc.subject | MELLITUS | - |
dc.subject | FLUTTER | - |
dc.subject | STROKE | - |
dc.subject | SYSTEM | - |
dc.subject | COHORT | - |
dc.title | The impact of body weight and diabetes on new-onset atrial fibrillation: a nationwide population based study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yun Gi | - |
dc.contributor.affiliatedAuthor | Choi, Jong-Il | - |
dc.contributor.affiliatedAuthor | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | Kim, Young-Hoon | - |
dc.identifier.doi | 10.1186/s12933-019-0932-z | - |
dc.identifier.scopusid | 2-s2.0-85072847535 | - |
dc.identifier.wosid | 000488495700002 | - |
dc.identifier.bibliographicCitation | CARDIOVASCULAR DIABETOLOGY, v.18, no.1 | - |
dc.relation.isPartOf | CARDIOVASCULAR DIABETOLOGY | - |
dc.citation.title | CARDIOVASCULAR DIABETOLOGY | - |
dc.citation.volume | 18 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | CATHETER ABLATION | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | INDEPENDENT RISK | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | MELLITUS | - |
dc.subject.keywordPlus | FLUTTER | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | COHORT | - |
dc.subject.keywordAuthor | Atrial fibrillation | - |
dc.subject.keywordAuthor | Body weight | - |
dc.subject.keywordAuthor | Waist circumference | - |
dc.subject.keywordAuthor | Diabetes | - |
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