Blood pressure variability in subacute stage and risk of major vascular events in ischemic stroke survivors
DC Field | Value | Language |
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dc.contributor.author | Kang, Jihoon | - |
dc.contributor.author | Kim, Beom Joon | - |
dc.contributor.author | Yang, Mi Hwa | - |
dc.contributor.author | Jang, Myung Suk | - |
dc.contributor.author | Han, Moon-Ku | - |
dc.contributor.author | Lee, Ji Sung | - |
dc.contributor.author | Gorelick, Philip B. | - |
dc.contributor.author | Lee, Juneyoung | - |
dc.contributor.author | Bae, Hee-Joon | - |
dc.date.accessioned | 2021-09-01T04:48:21Z | - |
dc.date.available | 2021-09-01T04:48:21Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 0263-6352 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/62592 | - |
dc.description.abstract | Background: We aimed to investigate whether blood pressure (BP) in the subacute stage of ischemic stroke affects subsequent vascular events after acute ischemic stroke. Methods: From a prospective stroke registry database, consecutive ischemic stroke patients arriving within 48 h of onset were identified. The mean and SD of SBP per patient (SBPmean and SBPSD) in the subacute stage (from 72 h of onset to discharge), were calculated. Primary outcome was a composite of stroke, myocardial infarction and vascular death that occurred within 1 year after hospital discharge. A Cox proportional hazards model was applied to elucidate whether the increase of SBPmean and SBPSD would increase the hazards of the primary outcome. Results: Of 4415 patients (age, 66.7 +/- 13.2 years; men, 69.5%), mean +/- SD of SBPmean and SBPSD in the subacute stage was 137.3 +/- 15.4 and 13.3 +/- 3.9 mmHg, respectively. Primary outcome events occurred in 6.9% during the first year after stroke. There was a significant dose-response relationship between the SBPSD and the risk of the primary outcome (P = 0.004), but not between SBPmean and the risk (P = 0.78). Interpolating the change of adjusted hazard ratio using restricted cubic spine function suggested an existence of a threshold effect of SBPSD and a U-shaped relationship of SBPmean for the composite event. Conclusion: This study shows that BP variability but not mean BP in the subacute stage of ischemic stroke may increase 1-year risk of major vascular events in patients surviving its acute stage. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | NEUROLOGICAL DETERIORATION | - |
dc.subject | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject | MANAGEMENT | - |
dc.subject | RECOVERY | - |
dc.subject | OUTCOMES | - |
dc.subject | LEVEL | - |
dc.title | Blood pressure variability in subacute stage and risk of major vascular events in ischemic stroke survivors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Juneyoung | - |
dc.identifier.doi | 10.1097/HJH.0000000000002126 | - |
dc.identifier.scopusid | 2-s2.0-85071453438 | - |
dc.identifier.wosid | 000506869000012 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HYPERTENSION, v.37, no.10, pp.2000 - 2006 | - |
dc.relation.isPartOf | JOURNAL OF HYPERTENSION | - |
dc.citation.title | JOURNAL OF HYPERTENSION | - |
dc.citation.volume | 37 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2000 | - |
dc.citation.endPage | 2006 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | NEUROLOGICAL DETERIORATION | - |
dc.subject.keywordPlus | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | RECOVERY | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | LEVEL | - |
dc.subject.keywordAuthor | blood pressure | - |
dc.subject.keywordAuthor | cerebral infarction | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | stroke | - |
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