Eicosapentaenoic Acid (EPA) Modulates Glucose Metabolism by Targeting AMP-Activated Protein Kinase (AMPK) Pathway
- Authors
- Kim, Nami; Kang, Mi Sun; Nam, Miso; Kim, Shin Ae; Hwang, Geum-Sook; Kim, Hyeon Soo
- Issue Date
- 10월-2019
- Publisher
- MDPI
- Keywords
- AMPK; EPA; GLUT4; oxygen consumption
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.20, no.19
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Volume
- 20
- Number
- 19
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/62593
- DOI
- 10.3390/ijms20194751
- ISSN
- 1661-6596
- Abstract
- EPA, an omega-3 polyunsaturated fatty acid, exerts beneficial effects on human health. However, the molecular mechanisms underlying EPA function are poorly understood. The object was to illuminate molecular mechanism underlying EPA's role. Here, H-1-NMR-based metabolic analysis showed enhanced branched-chain amino acids (BCAAs) and lactate following EPA treatment in skeletal muscle cells. EPA regulated mitochondrial oxygen consumption rate. Furthermore, EPA induced calcium/calmodulin-dependent protein kinase kinase (CaMKK) through the generation of intracellular calcium. This induced the phosphorylation of AMP-activated protein kinase (AMPK) and p38 mitogen-activated protein kinase (p38 MAPK) that led to glucose uptake, and the translocation of glucose transporter type 4 (GLUT4) in muscles. In conclusion, EPA exerts benign effects on glucose through the activation of AMPK-p38 MAPK signaling pathways in skeletal muscles.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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