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An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies

Authors
Lu, QiliHarmalkar, Dipesh S.Choi, YongseokLee, Kyeong
Issue Date
10월-2019
Publisher
MDPI
Keywords
saturated oxygen heterocycles; cyclic ethers; total synthesis
Citation
MOLECULES, v.24, no.20
Indexed
SCIE
SCOPUS
Journal Title
MOLECULES
Volume
24
Number
20
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/62649
DOI
10.3390/molecules24203778
ISSN
1420-3049
Abstract
Saturated oxygen heterocycles are widely found in a broad array of natural products and other biologically active molecules. In medicinal chemistry, small and medium rings are also important synthetic intermediates since they can undergo ring-opening and -expansion reactions. These applications have driven numerous studies on the synthesis of oxygen-containing heterocycles and considerable effort has been devoted toward the development of methods for the construction of saturated oxygen heterocycles. This paper provides an overview of the biological roles and synthetic strategies of saturated cyclic ethers, covering some of the most studied and newly discovered related natural products in recent years. This paper also reports several promising and newly developed synthetic methods, emphasizing 3-7 membered rings.
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생명과학대학 (생명공학부)
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