Short-term effects of anti-vascular endothelial growth factor on peripapillary choroid and choriocapillaris in eyes with neovascular age-related macular degeneration
DC Field | Value | Language |
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dc.contributor.author | Lee, Boram | - |
dc.contributor.author | Yoo, Gyeongmin | - |
dc.contributor.author | Yun, Cheolmin | - |
dc.contributor.author | Oh, Jaeryung | - |
dc.date.accessioned | 2021-09-01T04:58:21Z | - |
dc.date.available | 2021-09-01T04:58:21Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 0721-832X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/62666 | - |
dc.description.abstract | Purpose To investigate the effects of anti-vascular endothelial growth factor (anti-VEGF) on the peripapillary choroid and choriocapillaris in eyes with neovascular age-related macular degeneration (nAMD). Methods We included consecutive patients who underwent three monthly intravitreal injections of aflibercept or ranibizumab for nAMD, followed by swept-source optical-coherence tomography angiography (SS-OCTA). Peripapillary choroidal thickness (CT) and vascular density (VD) of the peripapillary choriocapillaris were measured in SS-OCT and OCTA images at baseline and at 1 month after three monthly injections of anti-VEGF. Results In 68 eyes of 68 patients with nAMD, peripapillary CT decreased from 124.5 +/- 69.9 mu m to 116.5 +/- 68.2 mu m (P = 0.003) after three monthly intravitreal injections of anti-VEGF. The mean vascular density (VD) of the peripapillary choriocapillaris also decreased from 73.99 +/- 6.33 to 71.82 +/- 6.51 (P < 0.001). The change in the peripapillary choriocapillaris VD was significantly affected by baseline peripapillary choriocapillaris VD, baseline peripapillary CT, and type of nAMD (P = 0.004, P = 0.028, P = 0.015, respectively). The baseline VD of the choriocapillaris was lower in non-responders (median, 70.63; 25-75%, 68.12-71.27) than in responders (median, 75.32; 25-75%, 70.09-79.96) (P = 0.032). Conclusion These results suggest that anti-VEGF injection influences the peripapillary choriocapillaris flow out of exudative lesions, and that its effects depend on the baseline status of the choroid and choriocapillaris. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | ANTI-VEGF THERAPY | - |
dc.subject | INTRAVITREAL AFLIBERCEPT | - |
dc.subject | RANIBIZUMAB INJECTIONS | - |
dc.subject | THICKNESS | - |
dc.subject | SUBFOVEAL | - |
dc.title | Short-term effects of anti-vascular endothelial growth factor on peripapillary choroid and choriocapillaris in eyes with neovascular age-related macular degeneration | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yun, Cheolmin | - |
dc.contributor.affiliatedAuthor | Oh, Jaeryung | - |
dc.identifier.doi | 10.1007/s00417-019-04432-w | - |
dc.identifier.scopusid | 2-s2.0-85069926495 | - |
dc.identifier.wosid | 000496711200012 | - |
dc.identifier.bibliographicCitation | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, v.257, no.10, pp.2163 - 2172 | - |
dc.relation.isPartOf | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | - |
dc.citation.title | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | - |
dc.citation.volume | 257 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2163 | - |
dc.citation.endPage | 2172 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.subject.keywordPlus | ANTI-VEGF THERAPY | - |
dc.subject.keywordPlus | INTRAVITREAL AFLIBERCEPT | - |
dc.subject.keywordPlus | RANIBIZUMAB INJECTIONS | - |
dc.subject.keywordPlus | THICKNESS | - |
dc.subject.keywordPlus | SUBFOVEAL | - |
dc.subject.keywordAuthor | Optical coherence tomography angiography | - |
dc.subject.keywordAuthor | Peripapillary choriocapillaris | - |
dc.subject.keywordAuthor | Peripapillary choroidal thickness | - |
dc.subject.keywordAuthor | Age-related macular degeneration | - |
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