Alcohol intake and risk of rheumatoid arthritis: a Mendelian randomization study
DC Field | Value | Language |
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dc.contributor.author | Bae, S. -C. | - |
dc.contributor.author | Lee, Y. H. | - |
dc.date.accessioned | 2021-09-01T05:05:57Z | - |
dc.date.available | 2021-09-01T05:05:57Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 0340-1855 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/62732 | - |
dc.description.abstract | Objective. To examine whether alcohol intake is causally associated with rheumatoid arthritis (RA). Methods. We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics of alcohol intake frequency from the UK Biobank genome-wide association studies (GWASs; n = 336,965) as the exposure and a GWAS meta-analysis of 5539 autoantibody-positive RA patients and 20,169 controls as the outcome. Results. We selected 24 single nucleotide polymorphisms (SNPs) associated with alcohol intake frequency at genome-wide significance as instrumental variables (IVs) to improve inference, 16 of which were inversely associated with RA. The IVW method showed no evidence of a causal association between alcohol intake and RA (beta = 0.218, SE = 0.213, p = 0.306). The MR-Egger regression revealed that directional pleiotropy was unlikely to bias the result (intercept = 0.027, p = 0.292). The MR-Egger analysis and the weighted median approach showed no causal association between alcohol intake and RA (beta = -0.778, SE = 0.947, p = 0.420 and beta = -0.286, SE = 0.302, p = 0.344, respectively). Cochran's Q test did not indicate heterogeneity between IV estimates based on the individual variants, and results from a "leave-one-out" analysis demonstrated that no single SNP was driving the IVW point estimate. Conclusion. The MR analysis does not support a causal inverse association between alcohol intake and RA occurrence. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | GENOME-WIDE ASSOCIATION | - |
dc.subject | INSTRUMENTAL VARIABLES | - |
dc.subject | GENETIC-VARIANTS | - |
dc.subject | METAANALYSIS | - |
dc.subject | BIAS | - |
dc.title | Alcohol intake and risk of rheumatoid arthritis: a Mendelian randomization study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Y. H. | - |
dc.identifier.doi | 10.1007/s00393-018-0537-z | - |
dc.identifier.scopusid | 2-s2.0-85053552745 | - |
dc.identifier.wosid | 000489757900013 | - |
dc.identifier.bibliographicCitation | ZEITSCHRIFT FUR RHEUMATOLOGIE, v.78, no.8, pp.791 - 796 | - |
dc.relation.isPartOf | ZEITSCHRIFT FUR RHEUMATOLOGIE | - |
dc.citation.title | ZEITSCHRIFT FUR RHEUMATOLOGIE | - |
dc.citation.volume | 78 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 791 | - |
dc.citation.endPage | 796 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | INSTRUMENTAL VARIABLES | - |
dc.subject.keywordPlus | GENETIC-VARIANTS | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | BIAS | - |
dc.subject.keywordAuthor | Alcohol intake | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | Mendelian randomization | - |
dc.subject.keywordAuthor | Genetic predisposition to disease | - |
dc.subject.keywordAuthor | Genome-wide association study | - |
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