Essential Role of Protein Arginine Methyltransferase 1 in Pancreas Development by Regulating Protein Stability of Neurogenin 3
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kanghoon | - |
dc.contributor.author | Kim, Hyunki | - |
dc.contributor.author | Lee, Joonyub | - |
dc.contributor.author | Oh, Chang Myung | - |
dc.contributor.author | Song, Heein | - |
dc.contributor.author | Kim, Hyeongseok | - |
dc.contributor.author | Koo, Seung Hoi | - |
dc.contributor.author | Lee, Junguee | - |
dc.contributor.author | Lim, Ajin | - |
dc.contributor.author | Kim, Hail | - |
dc.date.accessioned | 2021-09-01T05:07:38Z | - |
dc.date.available | 2021-09-01T05:07:38Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 2233-6079 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/62748 | - |
dc.description.abstract | Background: Protein arginine methyltransferase 1 (PRMT1) is a major enzyme responsible for the formation of methylarginine in mammalian cells. Recent studies have revealed that PRMT1 plays important roles in the development of various tissues. However, its role in pancreas development has not yet been elucidated. Methods: Pancreatic progenitor cell-specific Prmt1 knock-out (Prmt1 PKO) mice were generated and characterized for their metabolic and histological phenotypes and their levels of Neurog3 gene expression and neurogenin 3 (NGN3) protein expression. Protein degradation assays were performed in mPAC cells. Results: Prmt1 PKO mice showed growth retardation and a severely diabetic phenotype. The pancreatic size and beta-cell mass were significantly reduced in Prmt1 PKO mice. Proliferation of progenitor cells during the secondary transition was decreased and endocrine cell differentiation was impaired. These defects in pancreas development could be attributed to the sustained expression of NGN3 in progenitor cells. Protein degradation assays in mPAC cells revealed that PRMT1 was required for the rapid degradation of NGN3. Conclusion: PRMT1 critically contributes to pancreas development by destabilizing the NGN3 protein. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN DIABETES ASSOC | - |
dc.subject | METHYLATION | - |
dc.subject | PRMT1 | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | PROGENITORS | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | PLEXUS | - |
dc.subject | CARM1 | - |
dc.title | Essential Role of Protein Arginine Methyltransferase 1 in Pancreas Development by Regulating Protein Stability of Neurogenin 3 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Koo, Seung Hoi | - |
dc.identifier.doi | 10.4093/dmj.2018.0232 | - |
dc.identifier.scopusid | 2-s2.0-85075186898 | - |
dc.identifier.wosid | 000493403100011 | - |
dc.identifier.bibliographicCitation | DIABETES & METABOLISM JOURNAL, v.43, no.5, pp.649 - 658 | - |
dc.relation.isPartOf | DIABETES & METABOLISM JOURNAL | - |
dc.citation.title | DIABETES & METABOLISM JOURNAL | - |
dc.citation.volume | 43 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 649 | - |
dc.citation.endPage | 658 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002515670 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | METHYLATION | - |
dc.subject.keywordPlus | PRMT1 | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PROGENITORS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | PLEXUS | - |
dc.subject.keywordPlus | CARM1 | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | Islets of Langerhans | - |
dc.subject.keywordAuthor | Neurog3 protein | - |
dc.subject.keywordAuthor | mouse | - |
dc.subject.keywordAuthor | Pancreas | - |
dc.subject.keywordAuthor | Prmt1 protein | - |
dc.subject.keywordAuthor | mouse | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.