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Body Cavity- Based Lymphoma in a Country with Low Human Immunodeficiency Virus Prevalence: A Series of 17 Cases from the Consortium for Improving Survival of Lymphoma

Authors
Shin, JunghoonKo, Young HyehOh, Sung YongYoon, Dok HyunLee, Jeong-OkKim, Jin SeokPark, YongShin, Ho JinKim, Seok JinWon, Jong HoYoon, Sung-SooKim, Won SeogKoh, Youngil
Issue Date
10월-2019
Publisher
KOREAN CANCER ASSOCIATION
Keywords
Body cavity-based lymphoma; Primary effusion lymphoma; Human herpesvirus 8; Human immunodeficiency virus; Immunophenotype
Citation
CANCER RESEARCH AND TREATMENT, v.51, no.4, pp.1302 - 1312
Indexed
SCIE
SCOPUS
KCI
Journal Title
CANCER RESEARCH AND TREATMENT
Volume
51
Number
4
Start Page
1302
End Page
1312
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/62767
DOI
10.4143/crt.2018.555
ISSN
1598-2998
Abstract
Purpose Primary effusion lymphoma (PEL) is a type of body cavity-based lymphoma (BCBL). Most patients with PEL are severely immunocompromised and seropositive for human immunodeficiency virus (HIV). We investigated the distinctive clinicopathologic characteristics of BCBL in a country with low HIV burden. Materials and Methods We retrospectively collected data on the clinicopathologic characteristics, treatments, and outcomes of 17 consecutive patients with BCBL at nine institutions in Korea. Results Latency-associated nuclear antigen 1 (LANAI.) immunostaining indicated that six patients had PEL, six patients had human herpesvirus 8 (HHV8)-unrelated BCBL, and five patients had HHV8-unknown BCBL. The patients with PEL exhibited no evidence of immunodeficiency except for one who was HIV positive. One (20%) and four (80%) patients with PEL and six (100%) and zero (0%) patients with HHV8-unrelated BCBL were positive for CD20 and CD30 expression, respectively. The two patients with PEL (one HIV-positive and one HIV-negative patient) with the lowest proliferation activity as assessed by the Ki-67 labeling index survived for > 1 and > 4 years without chemotherapy, respectively, in contrast to the PEL cases in the literature, which mostly showed a high proliferation index and poor survival. Conclusion PEL mostly occurred in ostensibly immunocompetent individuals and had a favorable outcome in Korea. A watchful waiting approach may be applicable for managing HIV-seronegative patients with PEL with a low Ki-67 labeling index. A possible trend was detected among LANA1, CD20, and CD30 expression in BCBL.
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