Treatment Outcome after Fractionated Conformal Radiotherapy for Hepatocellular Carcinoma in Patients with Child-Pugh Classification B Korea (KROG 16-05)
DC Field | Value | Language |
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dc.contributor.author | Bae, Sun Hyun | - |
dc.contributor.author | Park, Hee Chul | - |
dc.contributor.author | Yoon, Won Sup | - |
dc.contributor.author | Yoon, Sang Min | - |
dc.contributor.author | Jung, In-Nye | - |
dc.contributor.author | Lee, Ik Jae | - |
dc.contributor.author | Kim, Jun Won | - |
dc.contributor.author | Seong, Jinsil | - |
dc.contributor.author | Kim, Tae Hyun | - |
dc.contributor.author | Nam, Taek-Keun | - |
dc.contributor.author | Choi, Youngmin | - |
dc.contributor.author | Lee, Sun Young | - |
dc.contributor.author | Jang, Hong Seok | - |
dc.contributor.author | Lee, Dong Soo | - |
dc.contributor.author | Kim, Jin Hee | - |
dc.date.accessioned | 2021-09-01T05:12:16Z | - |
dc.date.available | 2021-09-01T05:12:16Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/62785 | - |
dc.description.abstract | Purpose There is limited data on radiotherapy (RT) for hepatocellular carcinoma (FCC) in patients with Child-Pugh classification B (CP-B). This study aimed to evaluate the treatment outcomes of fractionated conformal RT in HCC patients with CP-B. Materials and Methods We retrospectively reviewed the data of HCC patients with CP-B treated with RT between 2009 and 2014 at 13 institutions in Korea. HCC was diagnosed by the Korea guideline of 2009, and modem RT techniques were applied. Fraction size was <= 5 Gy and the biologically effective dose (BED) >= 40 Gy(10) (alpha/beta=10 Gy). A total of 184 patients were included in this study. Results Initial CP score was seven in 62.0% of patients, eight in 31.0%, and nine in 7.0%. Portal vein tumor thrombosis was present in 66.3% of patients. The BED ranged from 40.4 to 89.6 Gyio (median, 56.0 Gyio). After RT completion, 48.4% of patients underwent additional treatment. The median overall survival (OS) was 9.4 months. The local progression-free survival and OS rates at 1 year were 58.9% and 39.8%, respectively. In the multivariate analysis, non-classic radiation-induced liver disease (RILD) (p < 0.001) and additional treatment (p < 0.001) were the most significant prognostic factors of OS. Among 132 evaluable patients without progressive disease, 19.7% experienced non-classic RILD. Normal liver volume was the most predictive dosimetric parameter of non-classic RILD. Conclusion Fractionated conformal RT showed favorable OS with a moderate risk non-classic RILD. The individual radiotherapy for CP-B could be cautiously applied weighing the survival benefits and the RILD risks. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN CANCER ASSOCIATION | - |
dc.subject | STEREOTACTIC BODY RADIOTHERAPY | - |
dc.subject | RADIATION-THERAPY | - |
dc.subject | TOXICITY | - |
dc.subject | TOLERANCE | - |
dc.subject | EFFICACY | - |
dc.subject | PATTERNS | - |
dc.title | Treatment Outcome after Fractionated Conformal Radiotherapy for Hepatocellular Carcinoma in Patients with Child-Pugh Classification B Korea (KROG 16-05) | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Won Sup | - |
dc.identifier.doi | 10.4143/crt.2018.687 | - |
dc.identifier.scopusid | 2-s2.0-85073184834 | - |
dc.identifier.wosid | 000489753500033 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, v.51, no.4, pp.1589 - 1599 | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.citation.title | CANCER RESEARCH AND TREATMENT | - |
dc.citation.volume | 51 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1589 | - |
dc.citation.endPage | 1599 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002514050 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | STEREOTACTIC BODY RADIOTHERAPY | - |
dc.subject.keywordPlus | RADIATION-THERAPY | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | TOLERANCE | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | PATTERNS | - |
dc.subject.keywordAuthor | Child-Pugh B | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
dc.subject.keywordAuthor | Hepatic toxicity | - |
dc.subject.keywordAuthor | Radiotherapy | - |
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