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Effect of sildenafil citrate on brain central fatigue after exhaustive swimming exercise in rats

Authors
Park, Sang-SeoKim, Tae-WoonKim, Chang-JuHong, Seo-YounKim, Bo-KyunSim, Young-JeShin, Mal-Soon
Issue Date
10월-2019
Publisher
KOREAN SOC EXERCISE REHABILITATION
Keywords
Sildenafil citrate; Central fatigue; Exhaustive exercise; Serotonin
Citation
JOURNAL OF EXERCISE REHABILITATION, v.15, no.5, pp.651 - 656
Indexed
SCOPUS
KCI
Journal Title
JOURNAL OF EXERCISE REHABILITATION
Volume
15
Number
5
Start Page
651
End Page
656
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/62788
DOI
10.12965/jer.1938582.291
ISSN
2288-176X
Abstract
Sildenafil citrate, a potent and selective inhibitor of phosphodiesterase type-5, is used clinically to treat erectile dysfunction and pulmonary arterial hypertension. We investigated the effect of sildenafil citrate on brain central fatigue through serotonin (5-hydroxytryptamine, 5-HT) synthesis after exhaustive swimming exercise in rats. The rats in the sildenafil citrate-treated groups received sildenafil citrate orally once a day for 14 consecutive days at respective dosage. On the 14 days after starting experiment, each animal was submitted to swimming test with intensity equivalent to overload. The exhaustion was defined as a state in which coordinated movements did not return to the water surface for breathing within 10 sec. Immunohistochemistry for 5-HT, tryptophan hydroxylase (TPH), and western blot for serotonergic type 1A (5-HT1(A)) receptor and 5-HT transporter (5-HTT) were performed. Exhaustive swimming exercise increased 5-HT and TPH expressions in the dorsal raphe and sildenafil citrate suppressed 5-HT and TPH expressions in the exhaustive swimming exercise rats. Exhaustive swimming exercise increased 5-HT1(A) receptor and 5-HTT expressions in the dorsal raphe and sildenafil citrate suppressed 5-HT1(A) receptor and 5-HTT expressions in the exhaustive swimming exercise rats. The significant suppressing effect appeared in the 20-mg/kg sildenafil citrate. Sildenafil citrate might be proposed as a potential ergogenic aid through anticentral fatigue.
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