Transition metal-free synthesis of quinazolinones using dimethyl sulfoxide as a synthon
- Authors
- Lee, Seohoo; Sim, Jaeuk; Jo, Hyeju; Viji, Mayavan; Srinu, Lanka; Lee, Kiho; Lee, Heesoon; Manjunatha, Vishwanath; Jung, Jae-Kyung
- Issue Date
- 21-9월-2019
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- ORGANIC & BIOMOLECULAR CHEMISTRY, v.17, no.35, pp.8067 - 8070
- Indexed
- SCIE
SCOPUS
- Journal Title
- ORGANIC & BIOMOLECULAR CHEMISTRY
- Volume
- 17
- Number
- 35
- Start Page
- 8067
- End Page
- 8070
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/62847
- DOI
- 10.1039/c9ob01629e
- ISSN
- 1477-0520
- Abstract
- Biologically important quinazolinones have been synthesized from 2-aminobenzamides and DMSO. The key feature of the reaction is the utilization of DMSO as a methine source for intramolecular oxidative annulation. The CNS depressant drug methaqualone has also been synthesized by our methodology. The present method involves the synthesis of quinazolinones with a broad substrate scope and a good yield.
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Collections - College of Pharmacy > Department of Pharmaceutical Science > 1. Journal Articles
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