A preliminary experience of moderate-intensity stereotactic body radiation therapy for ultra-central lung tumor
DC Field | Value | Language |
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dc.contributor.author | Park, Sunmin | - |
dc.contributor.author | Kim, Young | - |
dc.contributor.author | Yoon, Won Sup | - |
dc.contributor.author | Rim, Chai Hong | - |
dc.date.accessioned | 2021-09-01T07:13:43Z | - |
dc.date.available | 2021-09-01T07:13:43Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-09-02 | - |
dc.identifier.issn | 0955-3002 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/62923 | - |
dc.description.abstract | Purpose: Administration of stereotactic body radiation therapy (SBRT) to ultra-central (UC) lung tumors, generally defined as those abutting the proximal bronchial trees, is difficult due to concerns about serious toxicities. Therefore, our institution has performed moderate-intensity SBRT. Patients and methods: Patients with UC tumors underwent SBRT at a dose of 50-60 Gy in 10 fractions, with D-max in the target volume not exceeding 110% of the prescribed dose. The primary outcomes were tumor response and overall survival (OS). Results: From January 2017 to September 2018, we treated eight patients who had been diagnosed with UC tumors. The median follow-up time was 8.6 months (range: 2.7-14.9). Five of the eight patients (62.5%) showed a complete response (CR), two (25%) had a partial response (PR), and one (12.5%) had stable disease (SD); the response and disease control rates were 87.5% and 100%, respectively. Seven patients were alive with no evidence of disease or with controlled disease until the last follow-ups, except for one patient who died due to a non-RT cause at 3 months after SBRT. One patient experienced grade 2 esophageal pain and another had grade 1 cough. No grade 3 or higher toxicities were reported. Conclusion: Moderate-intensity SBRT might aid in achieving good control of UC tumors without excessive toxicities. Future studies involving larger numbers of patients and longer follow-up times are warranted to confirm the efficacy and feasibility. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | ABLATIVE RADIOTHERAPY | - |
dc.subject | CANCER | - |
dc.subject | BRACHYTHERAPY | - |
dc.subject | LOBECTOMY | - |
dc.subject | OUTCOMES | - |
dc.subject | TRIAL | - |
dc.subject | SBRT | - |
dc.title | A preliminary experience of moderate-intensity stereotactic body radiation therapy for ultra-central lung tumor | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Won Sup | - |
dc.contributor.affiliatedAuthor | Rim, Chai Hong | - |
dc.identifier.doi | 10.1080/09553002.2019.1626026 | - |
dc.identifier.scopusid | 2-s2.0-85067576458 | - |
dc.identifier.wosid | 000472251200001 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, v.95, no.9, pp.1287 - 1294 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | - |
dc.citation.title | INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | - |
dc.citation.volume | 95 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1287 | - |
dc.citation.endPage | 1294 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Nuclear Science & Technology | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Nuclear Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | ABLATIVE RADIOTHERAPY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | BRACHYTHERAPY | - |
dc.subject.keywordPlus | LOBECTOMY | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | SBRT | - |
dc.subject.keywordAuthor | Stereotactic body radiotherapy | - |
dc.subject.keywordAuthor | ultra-central tumor | - |
dc.subject.keywordAuthor | feasibility | - |
dc.subject.keywordAuthor | radiotherapy | - |
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