Developing a prediction model for disease-free survival from upper urinary tract urothelial carcinoma in the Korean population
DC Field | Value | Language |
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dc.contributor.author | Kim, Sung Han | - |
dc.contributor.author | Song, Mi Kyung | - |
dc.contributor.author | Hong, Bumsik | - |
dc.contributor.author | Kang, Seok Ho | - |
dc.contributor.author | Jeong, Byong Chang | - |
dc.contributor.author | Ku, Ja Hyun | - |
dc.contributor.author | Seo, Ho Kyung | - |
dc.date.accessioned | 2021-09-01T07:17:39Z | - |
dc.date.available | 2021-09-01T07:17:39Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2019-09 | - |
dc.identifier.issn | 2045-7634 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/62957 | - |
dc.description.abstract | Background In this study, we aimed to propose a validated prediction model for disease-free survival (DFS) after radical nephroureterectomy (RNU) in a Korean population with upper urinary tract urothelial carcinoma (UTUC). Methods We performed a retrospective review of 1561 cases of UTUC who underwent either open RNU (ONU, n = 906) or laparoscopic RNU (LNU, n = 615) from five tertiary Korean institutions between January 2000 and December 2012. Data were used to develop a prediction model using the Cox proportional hazards model. Prognostic factors were selected using the backward variable selection method. The prediction model performance was investigated using Harrell's concordance index (C-index) and Hosmer-Lemeshow type 2 statistics. Internal validation was performed using a bootstrap approach, and the National Cancer Center data set (n = 128) was used for external validation. Results A best-fitting prediction model with seven significant factors was developed. The C-index and two Hosmer-Lemeshow type statistics of the prediction model were 0.785 (95% CI, 0.755-0.815), 4.810 (P = 0.8506), and 5.285 (P = 0.8088). The optimism-corrected estimate through the internal validation was 0.774 (95% CI, 0.744-0.804) and the optimism-corrected calibration curve was close to the ideal line with mean absolute error = 0.012. In external validation, the discrimination was 0.657 (95% CI, 0.560-0.755) and the two calibration statistics were 0.790 (P = 0.9397) and 3.103 (P = 0.5408), respectively. Conclusion A validated prediction model based on a large Korean RNU cohort was developed with acceptable performance to estimate DFS in patients with UTUC. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | CANCER-SPECIFIC SURVIVAL | - |
dc.subject | GOODNESS-OF-FIT | - |
dc.subject | RADICAL NEPHROURETERECTOMY | - |
dc.subject | INTRAVESICAL RECURRENCE | - |
dc.subject | POSTOPERATIVE NOMOGRAM | - |
dc.subject | VALIDATION | - |
dc.subject | SOCIETY | - |
dc.title | Developing a prediction model for disease-free survival from upper urinary tract urothelial carcinoma in the Korean population | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Seok Ho | - |
dc.identifier.doi | 10.1002/cam4.2382 | - |
dc.identifier.scopusid | 2-s2.0-85068707055 | - |
dc.identifier.wosid | 000478523900001 | - |
dc.identifier.bibliographicCitation | CANCER MEDICINE, v.8, no.11, pp.4967 - 4975 | - |
dc.relation.isPartOf | CANCER MEDICINE | - |
dc.citation.title | CANCER MEDICINE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 4967 | - |
dc.citation.endPage | 4975 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | CANCER-SPECIFIC SURVIVAL | - |
dc.subject.keywordPlus | GOODNESS-OF-FIT | - |
dc.subject.keywordPlus | RADICAL NEPHROURETERECTOMY | - |
dc.subject.keywordPlus | INTRAVESICAL RECURRENCE | - |
dc.subject.keywordPlus | POSTOPERATIVE NOMOGRAM | - |
dc.subject.keywordPlus | VALIDATION | - |
dc.subject.keywordPlus | SOCIETY | - |
dc.subject.keywordAuthor | nephroureterectomy | - |
dc.subject.keywordAuthor | prediction model | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | survival | - |
dc.subject.keywordAuthor | urothelial carcinoma | - |
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